Results 71 to 80 of about 2,059,935 (301)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Effects of verbal encouragement on performance of the multistage 20 m shuttle run

open access: yesActa Scientiarum. Health Sciences, 2015
Exertion tests for predicting maximal oxygen uptake (VO2) intend to estimate the person maximum performance. Some articles mention the verbal encouragement in their protocol to reach it, while others do not.
José Marinho Dias Neto   +5 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

New horizons for aerobic fitness normalization in children: Breaking the paradigm

open access: yesRevista Brasileira de Cineantropometria e Desempenho Humano, 2014
Traditional methods to normalize aerobic fitness (VO2max) have been considered inadequate for not properly adjusting the effects of body size in children, adolescents and adults.
Giovani dos Santos Cunha   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Validity of a squash-specific fitness test [PDF]

open access: yes, 2009
Purpose: This study examined the validity of a squash-specific test designed to assess endurance capability and aerobic power. Methods: Eight squash players and eight runners performed, in a counterbalanced order, incremental treadmill (TT) and squash ...
Wilkinson, Mick   +5 more
core  

Absolute and relative accelerometer thresholds for determining the association between physical activity and metabolic syndrome in the older adults: The Generation-100 study

open access: yesBMC Geriatrics, 2017
Background When assessing population adherence to physical activity (PA) recommendation using accelerometers, absolute intensity threshold definition is applied despite having limited validity in those with low cardiorespiratory fitness (CRF), who are ...
Nina Zisko   +9 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

open access: yesFEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer   +7 more
wiley   +1 more source

Oxygen uptake under normoxic condition in the Asian brown mussel Modiolus metcalfei (Bivalvia : Mytilidae) [PDF]

open access: yes, 2007
In the Asian brown mussel, Modiolus metcalfei, the oxygen uptake was examined under normoxic condition at 15.2℃. The ventilation volume per body weight (TW), wet weight of soft part (WW) and dry weight of molluscous part (DW) were 2.13L/min/kg TW, 5.23L ...
40416467   +12 more
core  

Maximal and anaerobic threshold cardiorespiratory responses during deepwater running

open access: yesRevista Brasileira de Cineantropometria e Desempenho Humano, 2014
Aquatic exercises provide numerous benefits to the health of their practitioners. To secure these benefits, it is essential to have proper prescriptions to the needs of each individual and, therefore, it is important to study the cardiorespiratory ...
Ana Carolina Kanitz   +7 more
doaj   +1 more source

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