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Development and In Vitro Evaluation of Mucoadhesive In Situ Nasal Gel of Oxymetazoline Hydrochloride: A Novel Approach for Nasal Drug Delivery

International Journal of Biological and Environmental Investigations
: Nasal mucosa has a high blood perfusion rate in the nasal cavity, which increases the drug's absorption and bioavailability in the systemic circulation compared to other routes.
Arya Dheerendra Kumar   +1 more
semanticscholar   +1 more source

Determination of the Nasal Decongestant, Oxymetazoline Hydrochloride, in Pharmaceutical Formulations by Hplc

Drug Development and Industrial Pharmacy, 1989
AbstractA liquid chromatographic procedure for the analysis of oxymetazoline hydrochloride in pharmaceuticals utilizing reversedphase ion-pairing was developed. Isolation of the analyte was carried out under isocratic conditions with a octadecylsilane column and an aqueous mobile phase containing methanol (70%), acetic acid (1%) and 0.005M sodium ...
T. J. Hoffmann   +2 more
openaire   +1 more source

Evaluation of the dose-response relationship for intra-nasal oxymetazoline hydrochloride in normal adults

European Journal of Clinical Pharmacology, 1999
To evaluate the dose-response relationship of increasing doses of oxymetazoline compared with placebo in normal subjects, and to determine the sensitivities of rhinomanometry, acoustic rhinometry and symptoms in discriminating between differing doses of oxymetazoline in normal subjects.The study had a randomized, double-blind, placebo-controlled ...
Taverner, D.   +3 more
openaire   +3 more sources

Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC

Journal of Pharmaceutical and Biomedical Analysis, 2006
A high-performance liquid chromatography (HPLC) method with UV detection at 232 nm was developed and validated for the simultaneous determination of triamcinolone acetonide (TAA) and oxymetazoline hydrochloride (OXY) in nasal spray formulations. The chromatographic system consisted of a micro Bondapak CN column (150 mm x 3.9 mm), 5 microm particle size
Sirimas, Sudsakorn   +2 more
openaire   +2 more sources

Superficial nasal mucosal blood flow and nasal patency following topical oxymetazoline hydrochloride.

Annals of allergy, 1992
The objective of this study was to evaluate the effect of 60 micrograms oxymetazoline on nasal mucosal blood flow (NMBF) measured by laser Doppler velocimetry. Nasal airflow (measured by anterior rhinomanometry) and subjectively perceived airflow (measured by visual analog scales) were also evaluated.
T J, Witek   +5 more
openaire   +2 more sources

Izotonizace vodných roztoků léčiv. Oxymetazolin hydrochlorid.

2013
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Martina Kučerová Title of Thesis: Tonicity adjustment of aqueous solutions of drugs.
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce   +2 more
exaly  

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