A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics [PDF]
, 2018 G-protein-coupled receptors (GPCRs) represent one of the most important classes of drug targets. The discovery of new GCPR therapeutics would greatly benefit from the development of a generalizable high-throughput assay to directly monitor their ...
Frank, M. +5 more
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Acta poloniae pharmaceutica, 2001 An HPLC method for the separation of the oxymetazoline hydrochloride and the products of its decomposition was developed and validated. The determination was performed with a LiChrospher RP-18 column, mobile phase of methanol-H2O-triethylamine-sodium acetate (1 mol l(-1))-acetic acid (1.06 kg l(-1)) (130:60:6:2:1).
B, Stanisz, W, Nowiński
openaire +1 more source
An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation [PDF]
Accurately predicting the permeation of chemicals through human epithelial tissues is crucial for pharmaceutical therapeutic design and toxicology. Current mathematical models of multi-layered stratified squamous epithelium such as those in the oral ...
Bearon, Rachel N. +6 more
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, 2011 A simple spectrophotometric method is developed for the determination of oxymetazoline hydrochloride (OMCl) as pure and in its pharmaceutical preparations. The method is based on the oxidative coupling reaction of OMCl with 4-aminoantipyrine (4-A.A.P) in
S. Zakaria
semanticscholar +1 more source
Reformulating pharmaceuticals in low GWP propellants [PDF]
Studies are being carried out in developing formulations for current and proprietary active pharmaceutical ingredients (APIs) to be delivered by a metered dose inhaler in HFC-152a or HFO-1234ze. Studies are being carried out on reformulating existing API
Anonymous,
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The stability of oxymetazoline hydrochloride in aqueous solution.
Acta poloniae pharmaceutica, 2002 The kinetics of the hydrolysis reaction of oxymetazoline hydrochloride in aqueous solution at three temperatures (343 K, 353 K, 363 K), over the pH-range 0.5-12.5 and ionic strength 0.5 has been investigated. The changes of concentration of oxymetazoline hydrochloride were followed by the HPLC method with UV detection.
openaire +1 more source
New aspects of the Slug Mucosal Irritation assay: predicting nasal stinging, itching and burning sensations [PDF]
, 2011 Adam +52 more
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Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid) [PDF]
, 2006 As peptides are not suitable for oral administration, they are generally administered parenterally. Due to the disadvantages associated with parenteral delivery alternative routes of administration (buccal, nasal, pulmonal, ocular, transdermal, rectal ...
Pringels, E
core
Comparative efficacy of oral fexofenadine hydrochloride and intranasal fluticasone furoate in patients with moderate to severe allergic rhinitis: A prospective randomized comparative study. [PDF]
Background Allergic rhinitis (AR) is a prevalent chronic condition with a significant impact on quality of life. Pharmacotherapy with non-sedating antihistamines and intranasal corticosteroids remains the mainstay, though comparative evidence in Indian ...
Dr .Praneeth Kumar K +3 more
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Establishment of framework for classification/categorisation and labelling of medicinal drugs and driving [PDF]
, 2011 The establishment of criteria for a European categorisation will have to serve most of the needs of all parties involved: health professionals, drug regulatory agencies, drug manufacturers and patients. Clear warnings and symbols are needed so patients
Fierro Lorenzo, María Inmaculada +2 more
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