Results 51 to 60 of about 1,802 (199)

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

The Effect of Oxytocics on the "Ca-Deficient" Uterus [PDF]

The Journal of General Physiology, 1959
If the excised, parturient rabbit uterus is repeatedly treated with a Krebs solution free from Ca, its tension in a tetanus drops gradually, and in 15 to 30 minutes becomes zero. We call such a uterus "Ca-deficient." The uterus in this condition has a high threshold, it is non-propagating, "inexcitable," fails to respond to oxytocics in a ...
E M, COUTINHO, A, CSAPO
openaire   +2 more sources

A prospective randomized controlled trial for comparison of oral misoprostol with methyl ergometrine in the third stage of labour for prevention of post-partum haemorrhage [PDF]

, 2017
Background: Near about 11% of women having live births have severe PPH (Globally 14 million women per year). About 3.9% of vaginal deliveries and 6.4% of cesarean section get PPH. Near about 1.4 million women die of PPH every year.
Sushma Gore, Pathan, Sabir Khan, Padmawar, Atul, Atul Padmawar, Sabir Khan Pathan, Gore, Sushma   +5 more
core   +1 more source

From guesstimates to game changers: Introducing objective measurement of blood loss for timely postpartum hemorrhage detection in Nigeria, Zambia, and Kenya

International Journal of Gynecology &Obstetrics, Volume 172, Issue S2, Page S17-S25, June 2026.
Abstract Accurate, timely diagnosis of postpartum hemorrhage (PPH) is critical for effective management. However, in low‐resource settings, reliance on visual estimation leads to missed diagnoses in up to 50% of cases, underscoring the need for more objective and reliable methods.
Rosemary Njogu, Hannah Tappis, Bright C. Orji, Sharon Kapoma, Victor Abiola Adepoju, Martha Ndhlovu, Elaine Roman, Michael Mwiti Muthamia, Eva Lathrop, Cherrie Evans   +9 more
wiley   +1 more source

Intramuscular methergine versus per-rectal misoprostol for prevention of atonic post-partum haemorrhage [PDF]

, 2018
Background: Postpartum haemorrhage (PPH), is a major hazard of maternal death which is accounting for 30% of deliveries with a 1% mortality rate globally.
Singangutti, Rajeshwari, Rajeshwari Singangutti   +1 more
core   +1 more source

Trends in Maternal Mortality in Bhutan: A National Review, 1985 to 2024

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Background Maternal mortality remains a major global public health concern, with the highest burden in low‐ and middle‐income countries. Despite global progress, preventable causes such as hemorrhage and hypertensive disorders continue to contribute significantly to maternal deaths.
Yeshey Dorjey, Deep Kiran Chhetri, Thinley Dorji, Sonam Gyamtsho   +3 more
wiley   +1 more source

A comparative study of different route of administration of misoprostol in the management of third stage of labour [PDF]

, 2017
Background: Post partum haemorrhage is the most common cause of maternal morbidity and mortality.  Misoprostol is a prostaglandin analogue, used for management of post partum haemorrhage. It can be used by various routes with minimal side effects.
H. S., Nethra, Vandana Ambastha, S., Sreelatha, Seema Nadagoudar, Ambastha, Vandana, Nethra H. S., Nadagoudar, Seema, ., Rajeshwari, Rajeshwari ., Sreelatha S.   +9 more
core   +1 more source

Midwives' Physiological Approach at the Third Stage of Labour: A Scoping Review

Birth, Volume 53, Issue 2, Page 231-244, June 2026.
Midwives play a crucial role in supporting a physiological third stage of labour by balancing trust in the woman's body with safety measures to prevent postpartum haemorrhage. This scoping review identifies key midwifery practices that promote natural placenta and highlights the importance of undisturbed, woman‐centred care.
Elena Tarlazzi, Virginia Berini, Lorenzo Brevi, Rosalba Ferrandino, Mara Tormen, Dila Parma, Rosaria Cappadona, Simona Fumagalli, Antonella Nespoli, Giuliana Simonazzi   +9 more
wiley   +1 more source

Which Uterotonic Is Better to Prevent the Postpartum Hemorrhage? Latest News in Terms of Clinical Efficacy, Side Effects, and Contraindications: A Systematic Review.

, 2013
Background:Postpartum hemorrhage (PPH) is a potentially fatal complication of vaginal and cesarean deliveries. The active management of the third stage of labor provides administration of prophylactic uterotonic drugs just before or immediately after ...
D'ANTONA, DONATO, Zambon A, Fagherazzi S, Bertocco A, DI GANGI, STEFANIA, Carrozzini M, GIZZO, SALVATORE, Patrelli TS, SACCARDI, CARLO, NARDELLI, GIOVANNI BATTISTA   +9 more
core   +1 more source