Results 171 to 180 of about 146,232 (352)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen   +2 more
wiley   +1 more source

Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation

open access: yesDevelopment, Growth &Differentiation, EarlyView.
ABSTRACT Adult organs exhibit remarkable plasticity, dynamically adjusting their size and function to meet physiological demands. The small‐intestinal epithelium, one of the most rapidly renewing tissues in mammals, undergoes extensive growth and remodeling in response to diet, injury, microbiota changes, and reproduction.
Tomotsune Ameku
wiley   +1 more source

Reduced plasma oxytocin levels in patients with open-angle glaucoma [PDF]

open access: hybrid
Yurina Yamada   +10 more
openalex   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani   +1 more
wiley   +1 more source

THE DESULFURIZATION OF OXYTOCIN

open access: yesJournal of Biological Chemistry, 1951
R A, TURNER, J G, PIERCE, V, DU VIGNEAUD
openaire   +2 more sources

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed   +8 more
wiley   +1 more source

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