Results 111 to 120 of about 99,222 (285)

A PD‐L1 Nanobody‐Engineered Synthetic RNA Virus Enhances Hepatocellular Carcinoma Immunotherapy by Interfering PCSK9 and Upregulating MHC‐I

Exploration, EarlyView.
A PD‐L1 nanobody‐engineered synthetic RNA virus (αPDL1‐VLPs/shPCSK9) is fabricated to inhibit PCSK9 and upregulate MHC‐I to facilitate T cells recognition of hepatocellular carcinoma (HCC). Moreover, αPDL1‐VLPs/shPCSK9 can recognize PD‐L1 and block the PD‐1/PD‐L1 pathway to prevent immune evasion, while promoting M2‐to‐M1 macrophages polarization ...
Chuyu Huang, Yun Ye, Yi Guo, Guozheng Liao, Linyi Luo, Lingwen Ding, Yingling Miao, Linping Zhao, Yongchang Ouyang, Shiying Li   +9 more
wiley   +1 more source

Büyükşehirlerde İlçelerin Adil Temsilini Sağlamak: Bir Model Önerisi

Journal of Political Administrative and Local Studies
Türkiye’de Büyükşehir Belediye (BŞB) meclisleri dolaylı yolla oluşmakta ve ilçeler seçim bölgesi olarak işlev yapmaktadır. Makalede BŞB meclislerinde ilçelerin adil temsil edilip edilmediği hususu ele alınmaktadır.
Erbay Arıkboğa
doaj  

Laatukäsikirja Rakennus Oy MTM:lle [PDF]

, 2020
Tämän toiminnallisen opinnäytetyön tavoitteena oli päivittää Vaasalaisen Rakennusliike MTM:n laatukäsikirjaa ja saada se sähköiseen muotoon. Laatukäsikirja on tarkoitettu yrityksen sisäiseen käyttöön, jota jaetaan ulkopuolelle pyydettäessä sekä ...
Torkko, Anttu
core  

Yerel Seçimlerde Adayın İmaj ve Tanınırlığının Etkisi: 31 Mart 2024 Yerel Seçimlerinde Isparta Örneği

SDÜ Vizyoner Dergisi
Yerel yönetimlerin ve yerel siyasetin ulusal siyasetin gölgesi altında şekillendiği uzun dönem tartışılan konu olmuştur. Türk siyasal hayatında yerel siyaset özellikle 1990’lı yıllara kadar ulusal siyasetin gölgesi altında gelişmiş olsa da sonrasında ...
Niran Cansever
doaj   +1 more source

Wir müssen reden: Kommunikation und Macht - ein garnicht so ungleiches Paar [PDF]

kommunikation@gesellschaft, 2000
Wir müssen reden: Kommunikation und Macht - ein gar nicht so ungleiches Paar Gottfried Oy verknüpft die Fäden der Debatte um das Demokratisierungspotential des Internets am Beispiel der medientheoretischen Vorstellungen über Interaktivität und ...
Gottfried Oy
doaj  

Sivutuotekalkkien hyötykäyttömahdollisuudet case Schaefer Kalk Finland Oy [PDF]

, 2019
Tämän opinnäytetyön toimeksiantaja oli Schaefer Kalk Finland Oy. Yritys valmistaa paperiteollisuudelle erilaisia valkaisu- ja täyteaineita. Schaefer Kalk Finland Oy toimii Kouvolassa UPM Kymin tehdasalueella.
Harjula, Meiju
core  

Reimbursement Design and Procedure‐Level Gross Profit of Robot‐Assisted Gastrectomy in a Publicly Financed Health System: Evidence From Japan

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Publicly financed healthcare systems must balance technological innovation with fiscal constraints. Reimbursement mechanisms influence institutional decisions regarding the adoption of high‐cost surgical technologies. This study evaluated whether current reimbursement designs adequately reflect procedure‐level gross surgical profit of robot ...
Yoshimasa Akashi, Koichi Ogawa, Yohei Owada, Tsuyoshi Enomoto, Kinji Furuya, Kazuhiro Takahashi, Osamu Shimomura, Yoshihiro Miyazaki, Tatsuya Oda   +8 more
wiley   +1 more source

Diabetes Increases Immunotherapy‐Related Toxicity but Not Efficacy in Metastatic Non‐Small Cell Lung Cancer: A Multicenter Retrospective Study

International Journal of Cancer, EarlyView.
ABSTRACT This multicenter retrospective study evaluated the impact of type 2 diabetes mellitus (DM) on clinical outcomes and immune‐related adverse events (irAEs) in 450 patients with metastatic non‐small cell lung cancer (NSCLC) treated with second‐line nivolumab at 17 centers between 2016 and 2024. Among these patients, 118 (26.2%) had DM.
Emre Çakır, Didem Divriklioğlu, Deniz Can Güven, Gamze Serin Özel, Oğuzhan Yıldız, Gamze Emin, Merve Keskinkılıç, Yeşim Ağyol, Onur Yazdan Balçık, Nagihan Kolkıran, Hale Gülçin Yıldırım Doğan, Pervin Can Şancı, Özge Yalıcı, Teoman Şakalar, Yurdagül Danacı, Yakup Düzköprü, Canan Yıldız, Mesut Yılmaz, İlhan Hacıbekiroğlu, Bülent Erdoğan, Saadettin Kılıçkap, Gamze Gököz Doğu, Melek Karakurt Eryılmaz, Atila Yıldırım, İlhan Öztop, İbrahim Vedat Bayoğlu, Şahnura Uzuntaş, Atike Pınar Erdoğan, Emir Çelik, Devrim Çabuk, Erdoğan Selçuk Şeber, Zehra Sadak Öcal, Hacer Demir   +32 more
wiley   +1 more source

Customer satisfaction model development of Ouman Oy

This study investigates the current customer service model of the thesis commissioner company Ouman Oy and aims to develop, suggest improvements and introduce an improved customer service model.
Kallovaara, Patrik
core  

Visceral Adipose Tissue as an Independent Predictor of Severe Post‐ERCP Pancreatitis: A Multicenter Retrospective Cohort Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP), known as post‐ERCP pancreatitis (PEP), is a major adverse event. Although risk factors for PEP incidence have been widely studied, factors associated with severe PEP remain unclear.
Shinya Uemura, Takuji Iwashita, Takuya Koizumi, Yosuke Ohashi, Shota Iwata, Akinori Maruta, Keisuke Iwata, Masahito Shimizu   +7 more
wiley   +1 more source