Results 191 to 200 of about 99,222 (285)

Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat‐Dose Administration for up to 14 Days

Alimentary Pharmacology &Therapeutics, EarlyView.
In this Phase 1 study, linaprazan glurate (LG) demonstrated rapid onset of intragastric acid suppression, achieving a pH > 4 within 10 to 60 min, and maintained pH control, with a 24‐h pH > 4 holding time ratio above 95% at 50 mg and 75 mg twice‐daily doses. AUC and Cmax of linaprazan, the main metabolite of LG, increased in proportion to LG dose.
Kajsa Larsson, Kjell Andersson, Gunilla Huledal, Jouni Junnila, Kristofer Katkits Nilsson, Elham Yektaei, Matjaž Fležar, Peter Unge   +7 more
wiley   +1 more source

Early support in occupational health care reduced work disability risk. [PDF]

Occup Med (Lond)
Siukola A, Korhonen M, Vähätalo L, Kervinen E, Reho T, Winell K, Viljamaa M, Sauni R.   +7 more
europepmc   +1 more source

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

Cancer Science, EarlyView.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia, Fengming Xu, Tao Zhou, Pingping Wang, Huiping Chen, Jing Zhang, Xiaochen Yuan, Haoxun Xu, Yu Ouyang   +8 more
wiley   +1 more source

Impedance Pneumography in Healthy and Sick Children Aged Between 2 and 35 Months. [PDF]

Pediatr Pulmonol
Beydon N, Roux EL, Boizeau P, Ioan I.
europepmc   +1 more source

Butyrate Modulates CXCR4 Expression and IL‐5‐Induced Inflammatory Responses in Human Eosinophils

Allergy, EarlyView.
Emiko Matsuyama, Jun Miyata, Yusuke Kawashima, Ryo Konno, Yoshinori Hasegawa, Masahito Mizobe, Yuri Fukasawa, Ryuta Onozato, Yo Otsu, Keeya Sunata, Hisashi Sasaki, Katsunori Masaki, Hiroki Kabata, Makoto Arita, Koichi Fukunaga   +14 more
wiley   +1 more source

Comprehensive Genomic Profiling Beyond Driver Testing in Non‐Squamous Non‐Small Cell Lung Cancer With Known Drivers

Cancer Science, EarlyView.
Figure 6 Comprehensive genomic profiling identified additional actionable alterations in a substantial proportion of patients with non‐squamous NSCLC despite previously identified driver alterations, with some findings leading to subsequent matched targeted therapies.
Yoshihiro Masui, Tatsuya Yoshida, Yoh Yamaguchi, Jun Miyakoshi, Ryoko Inaba Higashiyama, Akiko Tateishi, Yuki Shinno, Yuji Matsumoto, Yusuke Okuma, Tomonori Mizutani, Hidehito Horinouchi, Kouya Shiraishi, Takashi Kohno, Takafumi Koyama, Noboru Yamamoto, Yasushi Goto   +15 more
wiley   +1 more source

From 2D MXenes to 3D Carbides: Transformation of Ti₃C₂T_<i>z</i> Thin Films into TiC_<i>x</i> Carbide Nanolayers. [PDF]

Nano Lett
Ratzker B, Favelukis B, Krämer M, Freysoldt C, Kushnir Y, Nitsan A, Upcher A, Maman N, Messer O, Raabe D, Gault B, Sokol M.   +11 more
europepmc   +1 more source

Perioperative Durvalumab for Resectable NSCLC: Updated Outcomes for Japanese Patients in AEGEAN

Cancer Science, EarlyView.
In prespecified exploratory analyses of Japanese patients with resectable NSCLC enrolled in the AEGEAN trial, perioperative durvalumab plus neoadjuvant chemotherapy demonstrated clinically meaningful improvements in the primary endpoints of EFS and pCR versus neoadjuvant chemotherapy alone.
Tetsuya Mitsudomi, John V. Heymach, Yoshitsugu Horio, Fumihiro Tanaka, Hiroshi Tanaka, Shoichi Kuyama, Morihito Okada, Shinichi Toyooka, Yasutaka Watanabe, Martin Reck, David Harpole, Janis M. Taube, Yuka Olivo, Huiling Xiong, Tamer M. Fouad, Allen Chen, Hiroaki Akamatsu   +16 more
wiley   +1 more source

Salicylic acid and methanol-induced changes in enhancing rapeseed resilience to drought stress conditions. [PDF]

Sci Rep
Safajoo S, Faramarzi A, Ajalli J, Abdi M, Oraei M.   +4 more
europepmc   +1 more source

Mitochondria‐Directed Redox Phospholipid Polymers for Cancer Therapy

Cancer Science, EarlyView.
A mitochondria‐directed redox polymer containing an antioxidant‐oxidizing ferrocene unit and a triphenylphosphonium unit is prepared by a simple copolymerization strategy for cancer treatment. Incorporation of an appropriate amount of the directed unit enhances anticancer activity, elevates intracellular ROS levels, induces apoptosis, and suppresses in 
Yuma Kato, Yuki Ogawa, Akira Ito, Masahiro Kaneko   +3 more
wiley   +1 more source