Results 41 to 50 of about 13,905 (231)

TÜRKİYE’DE SEÇMEN TERCİHLERİNİN OLUŞMASINDA SEÇİM KAMPANYALARI VE SİYASAL PAZARLAMANIN ROLÜ ÜZERİNE BİR ARAŞTIRMA

Sosyal Ekonomik Araştırmalar Dergisi, 2012
Kamu Sektöründe modernizasyona duyulan ihtiyaç genelde vatandaşların hükümetlerine olan güvenlerinin seviyesinin düşük olmasından hareketle ortaya çıkar.
Süleyman KARAÇOR, Perihan GÖZÜM
doaj   +4 more sources

ÖRGÜT KÜLTÜRÜ İLE ÖRGÜTSEL YENİLİKÇİLİK ARASINDAKİ İLİŞKİDE ÖRGÜTSEL ÖĞRENMENİN ARACI ROLÜ

KAÜ-İİBF Dergisi, 2019
Yapılan çalışmanın amacı, Örgüt Kültürü (ÖK) ile Örgütsel Yenilikçilik (ÖY) değişkenleri arasındaki ilişkide Örgütsel Öğrenme (ÖÖ) değişkeninin aracılık rolünün olup olmadığını belirlemektir.
Kenan Orçanlı
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma

Oncology Letters, 2017
OY-TES-1 is a member of the cancer/testis antigen family that is expressed in healthy testis tissue and certain types of cancerous tissue. The present study aimed to analyze the expression pattern of OY-TES-1 and serum anti-OY-TES-1 antibody ...
Xi-sheng Li, Jun Yan, R. Fan, B. Luo, Qingmei Zhang, Yongda Lin, Sufang Zhou, Guorong Luo, Xiaoxun Xie, S. Xiao   +9 more
semanticscholar   +1 more source

ZnO Nanowires for Ultraviolet Detection: Recent Developments, Challenges, and Future Outlook

Advanced Electronic Materials, EarlyView.
This work provides a comprehensive review of Zinc Oxide (ZnO) nanowires for high‐performance ultraviolet (UV) photodetection. By analyzing unique device physics and various detector architectures, it unveils strategies to overcome current performance limitations regarding speed and sensitivity.
Ala K. Jehad, Salih Alper Akalin, Mustafa Erol, Yavuz Ozturk, Metin Yurddaskal   +4 more
wiley   +1 more source

Lymphocyte‐C‐Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Surgical site infection (SSI) is a major complication after ileal pouch–anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte‐to–C‐reactive protein ratio (LCR), a composite marker of systemic inflammation and immune/nutritional status, has emerged as a potential ...
Yuhki Koike, Koki Higashi, Yuki Sato, Yuka Nagano, Tadanobu Shimura, Takahito Kitajima, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa, Yuji Toiyama   +9 more
wiley   +1 more source

Very Long‐Term Outcomes of Laparoscopic Adjustable Gastric Banding in a Japanese Cohort: A Single‐Center 15‐Year Follow‐Up Study

Annals of Gastroenterological Surgery, EarlyView.
Long‐term outcomes of laparoscopic adjustable gastric banding (LAGB) in Japan were retrospectively evaluated in 28 patients with up to 15 years of follow‐up. LAGB achieved sustained long‐term weight reduction in selected patients; however, recurrence of metabolic comorbidities increased during extended follow‐up.
Yuichi Endo, Hiroomi Takayama, Wataru Miyoshino, Shun Nakamura, Yuiko Nagasawa, Masahiro Kawamura, Yoko Kawano, Takashi Masuda, Teijiro Hirashita, Yoshinori Ozeki, Takayuki Masaki, Hirotaka Shibata, Masafumi Inomata   +12 more
wiley   +1 more source