Results 41 to 50 of about 99,608 (285)

Asukkaiden käsitykset Kiinteistö Oy Kaarinan Vuokrataloista [PDF]

, 2020
Tämän opinnäytetyön aiheena on selvittää Kiinteistö Oy Kaarinan Vuokratalojen asukkaiden käsityksiä yrityksestä, sen imagosta ja markkinointiviestinnästä.
Kujanpää, Aino-Maria
core  

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

TÜRKİYE’DE SEÇMEN TERCİHLERİNİN OLUŞMASINDA SEÇİM KAMPANYALARI VE SİYASAL PAZARLAMANIN ROLÜ ÜZERİNE BİR ARAŞTIRMA

Sosyal Ekonomik Araştırmalar Dergisi, 2012
Kamu Sektöründe modernizasyona duyulan ihtiyaç genelde vatandaşların hükümetlerine olan güvenlerinin seviyesinin düşük olmasından hareketle ortaya çıkar.
Süleyman KARAÇOR, Perihan GÖZÜM
doaj   +4 more sources

Asiakastyytyväisyystutkimus : Case Kaskipuu Oy [PDF]

, 2019
Toimeksiantajana tälle opinnäytetyölle toimi Kaskipuu Oy. Yrityksen liiketoimintaan kuuluu ulko-ovien ja ikkunoiden valmistus Ylikiimingissä ja Viitasaarella sijaitsevilla tehtailla.
Manninen, Kallemarkus
core  

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Versionhallinta perehdytyksen työvälineenä Case: Oiwa Solutions Oy, Opintopolku 2.0 [PDF]

, 2020
Tämän opinnäyteytyön toimeksiantajana toimii Oiwa Solutions Oy. Opinnäytetyön tavoitteena oli päivittää toimeksiantoyritykselle aiemmin luotua opintopolkua vastaamaan enemmän toimeksiantajan tarpeita.
Jaakkola, Jonna
core  

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source

Yeni Medya Çağında Siyasi Bilgi Kaynakları ve Kanaat Önderlerinin Siyasi Tercihlere Etkisi: 16 Nisan Referandum Örneği

SDÜ Vizyoner Dergisi, 2021
Yeni medya araçları ile birlikte bilgi edinme kaynakları genişlemiş, kişiler günümüzde birçok kaynaktan siyasi konular hakkında bilgi edinebilir duruma gelmiştir.
Nurettin Güz, Zeynep Gazali Demirtaş
doaj   +1 more source