Results 201 to 210 of about 99,608 (285)

Ceramide-Phospholipid Risk Score Associates With Cardiovascular Events and Is Lowered by Atorvastatin, Simvastatin, and Anti-PCSK9 Treatments. [PDF]

J Cardiovasc Pharmacol
Hilvo M, Witoslawska A, Witoslawska A, Lääperi M, Jylhä A, Lyytikäinen LP, Päivä H, Laurikka J, März W, Karhunen PJ, Lehtimäki T, Laaksonen R.   +11 more
europepmc   +1 more source

Subcutaneous Allergen Immunotherapy With Thermosensitive Hydrogel and Recombinant Birch Pollen Allergen Variant, a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
A Phase 1, randomised, placebo‐controlled, dose‐escalation trial was performed with 30 birch pollen allergic subjects treated with DM‐101PX, that contains a recombinant hypoallergenic variant of Bet v 1 formulated with poloxamer 338 thermosensitive hydrogel.
Anna Nilson, Patricia Couroux, Jaana Haka, Silja Halme, Pekka Mattila, R. J. Joost van Neerven, Rolien Pels‐Rijcken, Janneke Ruinemans‐Koerts, Yvonne Schmidt‐Hieltjes, Anne Marie Salapatek, Kati Sallinen, Kristiina Takkinen, Daphne Tsitoura, Dirk‐Jan Opstelten, Juha Rouvinen   +14 more
wiley   +1 more source

CRB1‐Associated Inherited Retinal Dystrophies: Prospective Natural History Study With 4 Years of Follow‐Up

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background The lack of validated and sensitive clinical endpoints remains a major challenge in the design of gene therapy trials for inherited retinal dystrophies (IRDs). This prospective longitudinal cohort study describes the natural disease progression of IRDs caused by pathogenic mutations in the Crumbs homologue 1 (CRB1) gene, and ...
Jessica S. Karuntu, Xuan‐Thanh‐An Nguyen, Mays Talib, Mary J. van Schooneveld, Jan Wijnholds, Maria M. van Genderen, Jos Twisk, Nicoline E. Schalij‐Delfos, Caroline C. W. Klaver, Ralph J. Florijn, Jacoline B. ten Brink, Magda A. Smoor, L. Ingeborgh van den Born, Carel B. Hoyng, Alberta A. H. J. Thiadens, Camiel J. F. Boon   +15 more
wiley   +1 more source

Genetic Testing Unveils a Novel Thrombospondin‐1 Domain Containing Protein 1 Gene Variant as the Cause of Chronic Edema in a 79‐Year‐Old Woman

Clinical Genetics, EarlyView.
A 79‐year‐old woman with lifelong peripheral edema and an affected sister was found to harbor a novel homozygous THSD1 splice‐site variant. Reduced THSD1 expression in dermal endothelial cells supported the possibility that this variant contributes to chronic hereditary edema.
Eiko Amo, Takafumi Toyohara, Naoya Saijo, Satoko Sato, Jun Takayama, Yoshiko Suto, Yuji Noguchi, Sosuke Kinomura, Yusuke Ishizuka, Shun Watanabe, Koichi Kikuchi, Rui Makino, Mai Yoshida, Yuji Oe, Tasuku Nagasawa, Koji Okamoto, Takehiro Suzuki, Mariko Miyazaki, Shinya Kawaguchi, Takashi Suzuki, Takaaki Abe, Shigeo Kure, Atsuo Kikuchi, Tetsuhiro Tanaka   +23 more
wiley   +1 more source

Immersive virtual reality arm exercise, physical activity, and cardiometabolic health in cerebral palsy: A phase 1 trial

Developmental Medicine &Child Neurology, EarlyView.
In this pilot randomized trial, 32 young people with cerebral palsy used seated, telehealth‐delivered virtual reality exergaming for 12 weeks. Participants averaged 144 minutes per week of exercise and self‐reported physical activity increased by up to 166%, with favorable early changes in insulin (−45%) and triglycerides (−20%), while a waitlist ...
Byron Lai, Drew Davis, Raven Young, Ashley Wright, Robert A. Oster, Huacong Wen, Erin Swanson‐Kimani, Cynthia Wozow, Kelli Chaviano, Barbara Gower, James H. Rimmer   +10 more
wiley   +1 more source

Multi‐Dimensional Barriers for Work Productivity and Possible Solutions to Overcome Presenteeism in Young‐Onset Diabetes: A Mixed‐Methods Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Young‐onset non‐type 1 diabetes (YOD, age‐at‐diagnosis ≤ 40) is associated with poor physical and mental health, presenteeism and productivity loss. We examined patient‐perceived barriers to work productivity and key enablers to reduce presenteeism. Materials and Methods In this mixed‐methods study, we utilized validated questionnaires to
Kelly T. C. Wong, Jason D. C. Yin, Sunny C. S. Chan, Nga Sze Wong, Chun‐Kwan O, Yiming Dai, Yuzheng Zhang, Marques S.N. Ng, Risa Ozaki, Ronald C. W. Ma, Alice P. S. Kong, Andrea O. Y. Luk, Elaine Y.K. Chow, Juliana C. N. Chan, Juliana N. M. Lui   +14 more
wiley   +1 more source

Efficacy of Luseogliflozin Added to Semaglutide in Patients With Metabolic Dysfunction‐Associated Steatohepatitis and Type 2 Diabetes Mellitus: A Randomised, Open‐Label Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes drives the progression of metabolic dysfunction‐associated steatohepatitis (MASH). We evaluated whether antidiabetic therapy, specifically adding sodium–glucose cotransporter 2 (SGLT2) inhibitor to a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), improves liver histology in adults with biopsy‐proven MASH and type 2 ...
Teruki Miyake, Osamu Yoshida, Shinya Furukawa, Masashi Hirooka, Masanori Abe, Yoshio Tokumoto, Ayumi Kanamoto, Takao Watanabe, Ryo Yano, Yuki Okazaki, Atsushi Yukimoto, Yoshiko Nakamura, Eiji Takeshita, Teru Kumagi, Yoichi Hiasa   +14 more
wiley   +1 more source

Equine eyelid reconstruction by semi‐circular skin flap blepharoplasty

Equine Veterinary Education, EarlyView.
Summary Reconstructive surgeries of the equine eyelid carry significant challenges for the equine surgeon, due to the poorly mobile and tightly adhered facial skin in this species. Preservation of lid function is an essential surgical consideration in order to maintain protection of the globe and cornea and to provide ocular comfort to the case ...
V. J. Jordan, D. Leong, C. Hartley
wiley   +1 more source

Does Survey Angling CPUE Reflect Population Density of Northern Pike (Esox lucius) in Small Boreal Lakes?

Fisheries Management and Ecology, EarlyView.
ABSTRACT Knowing the relationship between catch per unit effort (CPUE) and population density is crucial for the management of recreational fisheries. We conducted standardized angling for pike in 16 lakes (3.4–22.1 ha) to test whether lure type, color, and pike density affect CPUE and the size of captured fish.
Aatu Turunen, Joni Tiainen, Mikko Olin, Anssi Vainikka   +3 more
wiley   +1 more source

Urinary Lipid Production Profile of Patients With Food Allergy

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto‐Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata   +10 more
wiley   +1 more source