Results 201 to 210 of about 29,522,340 (290)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Reflections upon Spenser's Discourses of Justice

open access: yes, 2018
P. Baseotto, O. Khalaf   +2 more
core  

As pol?ticas p?blicas e o papel social dos Institutos Federais de Educa??o, Ci?ncia e Tecnologia

open access: yes
O primeiro volume da s?rie Reflex?es na Educa??o busca resgatar os aspectos hist?ricos e legais sobre os Institutos Federais (IF), buscando informa??es desde o nascedouro da educa??o profissional e tecnol?gica no Brasil at? os dias atuais. Organizado com
Anjos, Maylta Brand?o dos   +1 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Decarboxylative cross-coupling reactions for P(O)-C bond formation. [PDF]

open access: yesRSC Adv, 2018
Hosseinian A   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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