Results 151 to 160 of about 461,399 (248)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Morphological and functional alterations in type 2 diabetes pancreata assessed with MRI-based metrics and [¹⁸F]FP-(+)-DTBZ PET. [PDF]

Front Endocrinol (Lausanne)
Nejati SF, Sadabad FE, Ren R, Huang Y, Bini J.   +4 more
europepmc   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Retrograde Double-Balloon Enteroscopy Endoscopic Retrograde Pancreatography With Interventional Radiology Rendezvous of a Transplanted Pancreas. [PDF]

ACG Case Rep J
Bayudan A, Wang M, Kolli P, Larsen M.
europepmc   +1 more source

Pancreatitis Aguda en el Puerperio: frecuencia en el Servicio de Cirugía General del Hospital General de Tlalnepantla [PDF]

, 2014
Gómez Cordero, Luis Roberto, Torres Vázquez, Aarón   +1 more
core  

Pancreatitis idiopática fibrosante como causa de ictericia obstructiva [PDF]

, 2005
Alconchel Gonzaga, S.P., Docobo Durántez, Fernando, García, R., Gómez Bravo, Miguel Ángel, Rodríguez Muñoz, Juan, Suárez Artacho, Gonzalo   +5 more
core   +2 more sources

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Importing pancreata for transplantation: a single-center experience across evolving allocation eras. [PDF]

Front Transplant
Tamburrini R, Hidalgo S, Leverson G, Kaufman DB, Neidlinger NA, Al-Adra DP, Aufhauser DD, Thiessen C, Mandelbrot D, Parajuli S, Odorico JS.   +10 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Bottoms up: A Rare Case of Rectal Cancer to the Pancreas. [PDF]

ACG Case Rep J
Al-Absi S, Lindsey JM, Melitas C.
europepmc   +1 more source