Results 31 to 40 of about 834,783 (289)

Modelação matemática da variação da temperatura do pé [PDF]

, 2013
Existem doenças que afetam diretamente a planta do pé, podendo ser um fator de elevada importância na qualidade de vida do indivíduo. Sabe-se que a presença de uma dada doença na planta do pé poderá afetar a normal distribuição da temperatura na planta ...
Carvalho, Soraia Leite, Pereira, Ana I.
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

On the interference of clinical outcome on rabies transmission an perpetuation

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
Rabies is a viral zoonotic infectious disease that affects mammals and is caused by genotypes/species of the Lyssavirus genus (Rhabdoviridae, Mononegavirales), with the genotype 1 (classic rabies virus - RABV) being the most prevalent. Despite continuous
PE Brandão
doaj   +1 more source

Origem, formação e conservação do gado Pé-Duro, o bovino do Nordeste brasileiro. [PDF]

, 2013
O gado Pé-Duro constitui recurso genético de grande importância a ser preservado, apresentando elevada rusticidade, com capacidade de produtividade sob condições consideradas críticas para sobrevivência.
ALMEIDA, M. J. de O., ARAUJO NETO, R. B. de, AZEVEDO, D. M. M. R., CARVALHO, G. M. C., FROTA, M. N. L. da, LEAL, T. M., LIMA NETO, A. F., MONTEIRO, F. das C.   +7 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Foot pain in the elderly associated to functional incapacity [PDF]

, 2012
BACKGROUND AND OBJECTIVES: Foot pain in elderly people may interfere with gait balance and cycle and may contribute for functional incapacity in the geriatric population. This study aimed at evaluating the frequency of functional incapacity associated to
Prato, Sabrina Canhada Ferrari, Santos, Fânia Cristina, Trevisani, Virgínia Fernandes Moça   +2 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Estudo da variação da temperatura na planta do pé [PDF]

, 2014
Como é de conhecimento comum, existem doenças que afetam diretamente a planta do pé, como é o caso da diabetes mellitus, que pode levar ao pé diabético.
Carvalho, Soraia Leite, Fernandes, Adília, Pereira, Ana I.   +2 more
core  

Displacement damage effects due to neutron and proton irradiations on CMOS image sensors manufactured in deep submicron technology [PDF]

, 2010
Displacement damage effects due to proton and neutron irradiations of CMOS image sensors dedicated to imaging are presented through the analysis of the dark current behavior in pixel arrays and isolated photodiodes. The mean dark current increase and the
Girard, Sylvain, Goiffon, Vincent, Inguimbert, Christophe, Magnan, Pierre, Petit, Sophie, Rolland, Guy, Saint-Pé, Olivier, Virmontois, Cédric   +7 more
core   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source