Results 211 to 220 of about 14,988,203 (289)

Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases. [PDF]

Hum Genet
Dang X, Wang FQ, Zhang C, Su H, Lei Y, Yang J, Lau YL, Yang W.   +7 more
europepmc   +1 more source

P-T conditions of cataclastic deformation associated with underplating: An example from the Cretaceous Shimanto complex, Kii Peninsula, SW Japan

, 2002
Y. Hashimoto, M. Enjoji, A. Sakaguchi, G. Kimura   +3 more
semanticscholar   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparative bioequivalence of 1 mg and 4 mg tacrolimus extended-release tablets: randomized, open label, fully replicate, crossover trials in healthy adult subjects. [PDF]

Front Nephrol
Sharma JK, Bunger D, Zaveri H, Chaturvedi A.   +3 more
europepmc   +1 more source

Along-strike variations of P–T conditions in accretionary wedges and syn-orogenic extension, the HP–LT Phyllite–Quartzite Nappe in Crete and the Peloponnese

, 2010
L. Jolivet, Fabien Trotet, P. Monié, O. Vidal, B. Goffé, L. Labrousse, P. Agard, B. Ghorbal   +7 more
semanticscholar   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Hypoxia Impairs CD8⁺ T Cell Fitness and Is Associated with a Dysfunctional CD8⁺ T Cell State in Pancreatic Cancer. [PDF]

Cancers (Basel)
Mello AM, Pasca di Magliano M, Lee KE.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. [PDF]

Proc Natl Acad Sci U S A
Xiang L, Hariharan A, Isaacs D, Weir N, Longden TA.   +4 more
europepmc   +1 more source