Results 121 to 130 of about 42,945,397 (252)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Ingeniería Mecánica, 2007 Los diagramas Tiempo Temperatura Transformación (TTT) de los aceros son de vital importancia para la industriavinculada a la elaboración de los aceros. El desarrollo alcanzado en la obtención de modelos matemáticos de estas curvasha permitido acercar al ...
R. Lobaina Sánchez, L. Goyos Pérez
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Singular bielliptic curves and Weierstrass points
Le Matematiche, 1999 Here we study the Weierstrass points of singular bielliptic curves in characteristic 0. Most of our results are existence results of the type "there exists a bielliptic curve Y with certain singular points and with a weierstrass point P ∈ Y_{reg} with a ...
Edoardo Ballico
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Quantile and probability curves without crossing [PDF]
The most common approach to estimating conditional quantile curves is to fit a curve, typically linear, pointwise for each quantile. Linear functional forms, coupled with pointwise fitting, are used for a number of reasons including parsimony of the ...
Alfred Galichon +2 more
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Construction of fetal growth curves and charts For cartagena and barranquilla population in Colombia
Revista Ciencias Biomédicas, 2010 We The great majority of the curves and intrauterine charts for ultrasound used in our population are base don studies in diferents populations, in relation to race and socioeconomic conditions to ours.We know the importance of determining gestational ...
Martínez-Gutiérrez Libardo +5 more
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