Results 61 to 70 of about 719,184 (218)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparative nonlinear analysis of a RC 2D frame soil-pile interaction [PDF]

open access: yesGrađevinski Materijali i Konstrukcije, 2018
Comparative non-linear static (NSA) and non-linear dynamic analyses (NDA) of 2D frames (as parts of skeletal 3D structures) of RC buildings founded on piles are presented in this paper.
Folić Boris, Folić Radomir
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

On the projective normality of Artin-Schreier curves

open access: yesLe Matematiche, 2013
In this paper we study the projective normality of certain Artin-Schreier curves Y_f defined over a field F of characteristic p by the equations y^q+y=f(x), q being a power of p and f in F[x] being a polynomial in x of degree m, with (m,p)=1.
Alberto Ravagnani, Edoardo Ballico
doaj  

Nonlinear Seismic Response of a Long-Span Suspension Bridge Under Sequential Ground Motions Considering Pile Foundation Soil–Structure Interaction

open access: yesCivilEng
This study presents the nonlinear seismic analysis of a large-scale suspension bridge under multiple sequential earthquake records. A detailed 3D finite element model is developed in SAP2000, incorporating CFST pylons, a composite deck, and a main cable ...
Lydia Konstantina Georgiou Zonara   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Statistical Evaluation of API P-Y Curve Model for Offshore Piles in Cohesionless Soils

open access: yesModelling
Pile foundations are widely used to support offshore wind turbines. While the p-y curve method is adopted for analysis of pile–soil interactions in popular design specifications, including the American Petroleum Institute (API), its accuracy remains ...
Peiyuan Lin, Xun Yuan, Tong Liu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Response of Monopiles Under Lateral Loading By Centrifuge Modeling

open access: yesنشریه مهندسی دریا, 2016
One of the most common methods to analyze and design monopiles under lateral load is load-displacement curves, particularly the p-y curves, at different locations of the structure.
Hamid Reza Khodaei   +2 more
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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