Results 1 to 10 of about 832,375 (231)

Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. [PDF]

Adv Pharmacol Sci, 2011
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli.
Tseng CS, Chen SM, Chien SC, Hsu KY.
europepmc   +8 more sources

A combined pig model to determine the net absorption of volatile fatty acids in the large intestine under different levels of crude fiber. [PDF]

Animal Model Exp Med, 2023
This research introduced the combined model of pigs with cannulation of blood vessel and terminal ileum fistula, and the deposition of volatile fatty acids (VFA) in large intestine was determined accurately by isotope tracer method to calculate net absorption of VFA.
Zhao S, Lv L, Wu T, Feng Z, Li Q, Lei L, Liu Z, Zhang H, Ren Y.   +8 more
europepmc   +3 more sources

Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging. [PDF]

Aging Cell, 2023
A comprehensive analysis of the gut metagenome and serum metabolome of individuals from a Chinese longevity cohort. We discovered distinct age‐dependent differences in both microbiota and serum metabolome. Through mediation analyses and fecal microbiota transplantation, we uncovered a potential causal relationship between the microbiota and metabolite ...
Sun L, Li Z, Hu C, Ding J, Zhou Q, Pang G, Wu Z, Yang R, Li S, Li J, Cai J, Sun Y, Li R, Zhen H, Sun S, Zhang J, Fang M, Chen Z, Lv Y, Cao Q, Sun Y, Gong R, Huang Z, Duan Y, Liu H, Dong J, Li J, Ruan J, Lu H, He B, Li N, Li T, Xue W, Li Y, Shen J, Yang F, Zhao C, Liang Q, Zhang M, Chen C, Gong H, Hou Y, Wang J, Zhang Y, Yang H, Zhu S, Xiao L, Jin Z, Guo H, Zhao P, Brix S, Xu X, Jia H, Kristiansen K, Yang Z, Nie C.   +55 more
europepmc   +2 more sources

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs. [PDF]

Physiol Rep
Abstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Morse R, Ten Have GAM, Thaden JJ, Engelen MPKJ, Rice S, Hagve M, Deutz NEP.   +6 more
europepmc   +2 more sources

Blood L-cystine levels positively related to increased risk of hypertension. [PDF]

J Clin Hypertens (Greenwich)
Abstract Hypertension is one component of metabolic syndrome (MetS). Here, the study evaluated hypertension‐associated metabolites in relation to other MetS components. Fasting plasma samples were collected from 22 hypertensive and 63 normotensive subjects for non‐targeted metabolomics.
Chen H, Deng Y, Zhou H, Wu W, Bao J, Cao D, Li Y, Feng Y.   +7 more
europepmc   +2 more sources

Effects of patent foramen ovale in migraine: a metabolomics-based study. [PDF]

J Physiol
Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Dong B, Li X, Zhang L, Liang G, Zheng W, Gui L, Ji S, Tang Y, Li H, Li W, Yang R, Li Y, Peng A, Chen Y, Gong M, Chen L.   +15 more
europepmc   +2 more sources

Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues. [PDF]

J Lipid Res
Microbe-produced molecules (xenometabolites) found in foods or produced by gut microbiota are increasingly implicated in microbe-microbe and microbe-host communication.
Sobhi HF, Mercer KE, Lan RS, Yeruva L, Ten Have GAM, Deutz NEP, Piccolo BD, Debédat J, Pack LM, Adams SH.   +9 more
europepmc   +3 more sources

Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in F1 rats in a sex‐dependent manner

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 6, November 2023., 2023
Maternal dexamethasone treatment caused glomerular hypertrophy and a decline in renal function and effective renal plasma flow in 4‐month‐old male offspring with no changes detected in females of the same age. The expression of sodium‐glucose transporter‐2 in renal membrane fractions was not affected by dexamethasone treatment suggesting that it does ...
Slava A. Malatiali, Narayana Kilarkaje, Maie Al‐Bader   +2 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

System Identification of the Low-Dose Kinetics of p-Aminohippuric Acid [PDF]

cclm, 1995
The renal clearance of p-aminohippuric acid, due to tubular secretion in addition to glomerular filtration, can only be determined by kinetic experiments. Maximal information can be gained from observed temporal marker concentration profiles by fitting dynamic mathematical models of the processes involved, such as absorption, distribution, and ...
Estelberger, Willibald, Zitta, Sabine, Lang, Thomas, Mayer, Frank, Mauric, Astrid, Horn, Sabine, Holzer, Herwig, Petek, Walter, Reibnegger, Gilbert   +8 more
openaire   +3 more sources