Results 1 to 10 of about 1,205 (134)

Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy [PDF]

Advances in Pharmacological Sciences, 2011
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli.
Chiao-Shih Tseng, Shih-Ming Chen, Shu-Chen Chien, Kuang-Yang Hsu   +3 more
doaj   +5 more sources

A combined pig model to determine the net absorption of volatile fatty acids in the large intestine under different levels of crude fiber [PDF]

Animal Models and Experimental Medicine, 2023
Background This study aimed to develop a combined model to quantify the net absorption of volatile fatty acids (VFA) in the large intestine (LI) of pigs. Methods Fifteen female growing pigs (Duroc × Large White × Landrace) were ranked by body weight (30 ±
Shengjun Zhao, Liangkang Lv, Taotao Wu, Zhi Feng, Qiang Li, Long Lei, Zhengya Liu, Hui Zhang, Ying Ren   +8 more
doaj   +3 more sources

Antiviral Activity of Acetylsalicylic Acid against Bunyamwera Virus in Cell Culture [PDF]

Viruses, 2023
The Bunyavirales order is a large group of RNA viruses that includes important pathogens for humans, animals and plants. With high-throughput screening of clinically tested compounds we have looked for potential inhibitors of the endonuclease domain of a
Sara Yolanda Fernández-Sánchez, José P. Cerón-Carrasco, Cristina Risco, Isabel Fernández de Castro   +3 more
doaj   +2 more sources

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs. [PDF]

Physiol Rep
Abstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Morse R, Ten Have GAM, Thaden JJ, Engelen MPKJ, Rice S, Hagve M, Deutz NEP.   +6 more
europepmc   +2 more sources

Assessment of Potential Drug-Drug Interactions for Novel Oral Melanocortin-1 Receptor Agonist Dersimelagon. [PDF]

Pharmacol Res Perspect
ABSTRACT Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin‐1 receptor. The drug–drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed ...
Ogasawara A, Ide R, Inoue S, Tsuda M, Teng R.   +4 more
europepmc   +2 more sources

Blood L-cystine levels positively related to increased risk of hypertension. [PDF]

J Clin Hypertens (Greenwich)
Abstract Hypertension is one component of metabolic syndrome (MetS). Here, the study evaluated hypertension‐associated metabolites in relation to other MetS components. Fasting plasma samples were collected from 22 hypertensive and 63 normotensive subjects for non‐targeted metabolomics.
Chen H, Deng Y, Zhou H, Wu W, Bao J, Cao D, Li Y, Feng Y.   +7 more
europepmc   +2 more sources

Urinary Metabolic Biomarkers of Attentional Control in Children With Attention-Deficit/Hyperactivity Disorder: A Dimensional Approach Through ¹H NMR-Based Metabolomics. [PDF]

NMR Biomed
This study identified five attentional control subgroups in school‐aged children, with and without ADHD, using VR‐based behavioral tests. NMR metabolomics revealed subgroup‐specific urinary metabolic profiles linked to energy and amino acid metabolism.
Salmerón ADM, Fernández-Martín P, Rodríguez-Herrera R, Arrabal-Campos FM, Abreu AC, Fernández I, Flores P.   +6 more
europepmc   +2 more sources

Relationship of Thyroid Function with Renal Hemodynamics and Cholesterol Metabolism in Proteinuric Kidney Disease: A Pilot Study [PDF]

Metabolites
Nephrotic syndrome and hypothyroidism are respectively reported to influence renal hemodynamics and hypercholesterolemia. However, the relationship of proteinuria-associated thyroid function with renal hemodynamics and cholesterol metabolism has yet to ...
Yoshitaka Iwazu, Kazuhiko Kotani, Taro Sugase, Daisuke Nagata, Toshiyuki Yamada   +4 more
doaj   +2 more sources

Surface modification with P-aminohippuric acid on biogenic apatite (fish bones) particles

Marine Science and Technology Bulletin, 2014
The aim of this study with fish bones as a waste in fish processing is to investigate whether they can provide more efficient and multi-functional materials by chemical modification.
Evren Tan, Bayram Kizilkaya, Nail Ucyol, Hasan Basri Ormanci, Ayhan Oral   +4 more
doaj   +4 more sources

Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

npj Breast Cancer, 2021
Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among ...
Oana A. Zeleznik, Raji Balasubramanian, Yibai Zhao, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Shelley S. Tworoger, A. Heather Eliassen   +8 more
doaj   +1 more source