Results 11 to 20 of about 2,429 (203)

Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging

Aging Cell, Volume 22, Issue 12, December 2023., 2023
A comprehensive analysis of the gut metagenome and serum metabolome of individuals from a Chinese longevity cohort. We discovered distinct age‐dependent differences in both microbiota and serum metabolome. Through mediation analyses and fecal microbiota transplantation, we uncovered a potential causal relationship between the microbiota and metabolite ...
Liang Sun, Zhiming Li, Caiyou Hu, Jiahong Ding, Qi Zhou, Guofang Pang, Zhu Wu, Ruiyue Yang, Shenghui Li, Jian Li, Jianping Cai, Yuzhe Sun, Rui Li, Hefu Zhen, Shuqin Sun, Jianmin Zhang, Mingyan Fang, Zhihua Chen, Yuan Lv, Qizhi Cao, Yanan Sun, Ranhui Gong, Zezhi Huang, Yong Duan, Hengshuo Liu, Jun Dong, Junchun Li, Jie Ruan, Haorong Lu, Benjin He, Ninghu Li, Tao Li, Wenbin Xue, Yan Li, Juan Shen, Fan Yang, Cheng Zhao, Qinghua Liang, Mingrong Zhang, Chen Chen, Huan Gong, Yong Hou, Jian Wang, Ying Zhang, Huanming Yang, Shida Zhu, Liang Xiao, Zhen Jin, Haiyun Guo, Peng Zhao, Susanne Brix, Xun Xu, Huijue Jia, Karsten Kristiansen, Ze Yang, Chao Nie   +55 more
wiley   +1 more source

Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in F1 rats in a sex‐dependent manner

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 6, November 2023., 2023
Maternal dexamethasone treatment caused glomerular hypertrophy and a decline in renal function and effective renal plasma flow in 4‐month‐old male offspring with no changes detected in females of the same age. The expression of sodium‐glucose transporter‐2 in renal membrane fractions was not affected by dexamethasone treatment suggesting that it does ...
Slava A. Malatiali, Narayana Kilarkaje, Maie Al‐Bader   +2 more
wiley   +1 more source

Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects

Kidney & Blood Pressure Research, 2020
Background: Cr is secreted by the proximal tubules and thus Cr clearance (Ccr) can overestimate inulin clearance (Cin). However, in some cases, Ccr can even underestimate Cin. This suggests that Cr could be reabsorbed in the tubuli.
Akihiro Tsuda, Eiji Ishimura, Yuri Machiba, Hideki Uedono, Shinya Nakatani, Katsuhito Mori, Junji Uchida, Masanori Emoto   +7 more
doaj   +1 more source

Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model

Pharmaceutics, 2022
Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional.
Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu   +4 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. [PDF]

PLoS ONE, 2013
Glutathione (GSH) is a negatively charged tripeptide, which is a major determinant of the cellular redox state and defense against oxidative stress. It is assembled inside and degraded outside the cells and is released under various physiological and ...
Ravshan Z Sabirov, Ranokon S Kurbannazarova, Nazira R Melanova, Yasunobu Okada   +3 more
doaj   +1 more source

Effects of dietary inclusion with rapeseed cake containing high glucosinolates on nitrogen metabolism and urine nitrous oxide emissions in steers

Animal Nutrition, 2022
Two consecutive trials were conducted to investigate the effects of glucosinolates (GLS) in rapeseed cake (RSC) on nitrogen (N) metabolism and urine nitrous oxide (N2O) emissions in steers. In trial 1, 8 steers and 4 levels of RSC, i.e.
Jian Gao, Bingbing Cheng, Yanfeng Sun, Yuchao Zhao, Guangyong Zhao   +4 more
doaj   +1 more source

Association of Noise Annoyance with Measured Renal Hemodynamic Changes

Kidney & Blood Pressure Research, 2021
Background: Chronic mental stress is recognized as a modifiable risk factor for cardiovascular disease. The aim of this study was to demonstrate that noise annoyance-induced stress is associated with changes in renal hemodynamics.
Dennis Kannenkeril, Susanne Jung, Christian Ott, Kristina Striepe, Julie Kolwelter, Roland E. Schmieder, Agnes Bosch   +6 more
doaj   +1 more source

Assessment of Potential Drug-Drug Interactions for Novel Oral Melanocortin-1 Receptor Agonist Dersimelagon. [PDF]

Pharmacol Res Perspect
ABSTRACT Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin‐1 receptor. The drug–drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed ...
Ogasawara A, Ide R, Inoue S, Tsuda M, Teng R.   +4 more
europepmc   +2 more sources

Evaluation of Drug‐Drug Interactions of Ensitrelvir, a SARS‐CoV‐2 3CL Protease Inhibitor, With Transporter Substrates Based on In Vitro and Clinical Studies

The Journal of Clinical Pharmacology, Volume 63, Issue 8, Page 918-927, August 2023., 2023
Abstract Drug‐drug interaction potentials of ensitrelvir, a novel oral inhibitor of 3C‐like protease of severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies. The target drug transporters assessed were P‐glycoprotein (P‐gp), breast cancer resistance protein (BCRP), organic anion ...
Ryosuke Shimizu, Takanobu Matsuzaki, Ryoko Oka, Takuhiro Sonoyama, Takahiro Fukuhara, Aya Kuwata, Yumiko Matsuo, Ryuji Kubota   +7 more
wiley   +1 more source