Results 21 to 30 of about 2,429 (203)

Renal hemodynamic effects differ between antidiabetic combination strategies: randomized controlled clinical trial comparing empagliflozin/linagliptin with metformin/insulin glargine

Cardiovascular Diabetology, 2021
Background Type 2 diabetes causes cardio-renal complications and is treated with different combination therapies. The renal hemodynamics profile of such combination therapies has not been evaluated in detail.
Christian Ott, Susanne Jung, Manuel Korn, Dennis Kannenkeril, Agnes Bosch, Julie Kolwelter, Kristina Striepe, Peter Bramlage, Mario Schiffer, Roland E. Schmieder   +9 more
doaj   +1 more source

Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging

Aging Cell, Volume 22, Issue 6, June 2023., 2023
This study depicted the metabolite and microbiota trajectories across aging. Long‐lived subjects from the familial longevity cohort harbored a distinguished microbiome signature. A candidate metabolite, pinane thromboxane A2 (PTA2), was consistently higher in the individuals of familial longevity and their descendants.
Junli Gong, Sanxin Liu, Shisi Wang, Hengfang Ruan, Qianqian Mou, Ping Fan, Tao Chen, Wei Cai, Yongjun Lu, Zhengqi Lu   +9 more
wiley   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial

Diabetes, Obesity and Metabolism, Volume 25, Issue 1, Page 198-207, January 2023., 2023
Abstract Aim To study the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor empagliflozin, the angiotensin receptor blocker (ARB) losartan, and their combination on blood pressure, while studying the mechanisms potentially involved. Methods A total of 24 people with type 2 diabetes (T2D) (age: 66 ± 6 years; body mass index: 31.0 ± 3 kg ...
Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte   +5 more
wiley   +1 more source

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

The moderate‐intensity continuous exercise maintains renal blood flow and does not impair the renal function

Physiological Reports, Volume 10, Issue 15, August 2022., 2022
Abstract Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that ...
Shotaro Kawakami, Tetsuhiko Yasuno, Saki Kawakami, Ai Ito, Kanta Fujimi, Takuro Matsuda, Shihoko Nakashima, Kosuke Masutani, Yoshinari Uehara, Yasuki Higaki, Ryoma Michishita   +10 more
wiley   +1 more source

Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model

Frontiers in Pharmacology, 2021
Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major impact on the disposition and pharmacokinetics of mainly renally excreted drugs.
Laura Dhondt, Siska Croubels, Peter De Paepe, Klara Goethals, Pieter De Cock, Pieter De Cock, Pieter De Cock, Mathias Devreese   +7 more
doaj   +1 more source

Splanchnic metabolism of nutrients and hormones in steers fed alfalfa under conditions of increased absorption of ammonia and L-arginine supply across the portal-drained viscera [PDF]

, 2005
Effects of increased ammonia and/or arginine absorption on net splanchnic (portal-drained viscera [PDV] plus liver) metabolism of nonnitrogenous nutrients and hormones in cattle were examined.
Assan, Bergman, Bruggemann, C. K. Reynolds, Chalupa, D. E. Beever, Davenport, Davenport, Demigne, Elsasser, Fernandez, Gow, Hammerman, Huntington, Krebs, Kuhara, Lobley, Lobley, M. A. Lomax, Maltby, Meijer, Milano, Morgan, Newsholme, Prior, Prior, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, S. A. Maltby, Seal, Spires, Taniguchi, Titheradge, Tyrrell, Vicini, Visek, Waterlow   +42 more
core   +1 more source

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science

Clinical Pharmacology &Therapeutics, Volume 111, Issue 6, Page 1222-1238, June 2022., 2022
Contrast‐induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)‐acetylcysteine (NAC) to reduce CIN led to > 70 clinical trials, 23 systematic reviews, and 2 large RCTs showing no benefit.
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston   +20 more
wiley   +1 more source

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma [PDF]

, 2019
In order to study the renal function, in terms of glomerular filtration and effective renal plasma flow, in broiler chickens and pigs, an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of ...
Croubels, Siska, De Baere, Siegrid, De Cock, Pieter, De Paepe, Peter, Devreese, Mathias, Dhondt, Laura   +5 more
core   +1 more source