Results 31 to 40 of about 1,406 (193)

The moderate‐intensity continuous exercise maintains renal blood flow and does not impair the renal function

Physiological Reports, Volume 10, Issue 15, August 2022., 2022
Abstract Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that ...
Shotaro Kawakami, Tetsuhiko Yasuno, Saki Kawakami, Ai Ito, Kanta Fujimi, Takuro Matsuda, Shihoko Nakashima, Kosuke Masutani, Yoshinari Uehara, Yasuki Higaki, Ryoma Michishita   +10 more
wiley   +1 more source

Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model

Frontiers in Pharmacology, 2021
Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major impact on the disposition and pharmacokinetics of mainly renally excreted drugs.
Laura Dhondt, Siska Croubels, Peter De Paepe, Klara Goethals, Pieter De Cock, Pieter De Cock, Pieter De Cock, Mathias Devreese   +7 more
doaj   +1 more source

Splanchnic metabolism of nutrients and hormones in steers fed alfalfa under conditions of increased absorption of ammonia and L-arginine supply across the portal-drained viscera [PDF]

, 2005
Effects of increased ammonia and/or arginine absorption on net splanchnic (portal-drained viscera [PDV] plus liver) metabolism of nonnitrogenous nutrients and hormones in cattle were examined.
Assan, Bergman, Bruggemann, C. K. Reynolds, Chalupa, D. E. Beever, Davenport, Davenport, Demigne, Elsasser, Fernandez, Gow, Hammerman, Huntington, Krebs, Kuhara, Lobley, Lobley, M. A. Lomax, Maltby, Meijer, Milano, Morgan, Newsholme, Prior, Prior, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, Reynolds, S. A. Maltby, Seal, Spires, Taniguchi, Titheradge, Tyrrell, Vicini, Visek, Waterlow   +42 more
core   +1 more source

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science

Clinical Pharmacology &Therapeutics, Volume 111, Issue 6, Page 1222-1238, June 2022., 2022
Contrast‐induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)‐acetylcysteine (NAC) to reduce CIN led to > 70 clinical trials, 23 systematic reviews, and 2 large RCTs showing no benefit.
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston   +20 more
wiley   +1 more source

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma [PDF]

, 2019
In order to study the renal function, in terms of glomerular filtration and effective renal plasma flow, in broiler chickens and pigs, an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of ...
Croubels, Siska, De Baere, Siegrid, De Cock, Pieter, De Paepe, Peter, Devreese, Mathias, Dhondt, Laura   +5 more
core   +1 more source

In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions

Pharmacology Research &Perspectives, Volume 10, Issue 3, June 2022., 2022
Mechanistic static pharmacokinetic models predict that CYP450 inhibition and induction are unlikely for fenfluramine or its major metabolite norfenfluramine at doses used for seizure reduction (0.2−0.7 mg/kg/day). These results suggest minimal drug‐drug interaction perpetrator potential for either fenfluramine or norfenfluramine.
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Brian W. Ogilvie, Steven Smith, Brooks Boyd   +5 more
wiley   +1 more source

Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2015
Obesity is an important risk factor for the development of chronic kidney disease. One of the major factors involved in the pathogenesis of obesity-associated kidney disease is glomerular hyperfiltration.
Boris Zingerman, Michal Herman-Edelstein, Arie Erman, Sarit Bar Sheshet Itach, Yaacov Ori, Benaya Rozen-Zvi, Uzi Gafter, Avry Chagnac   +7 more
doaj   +1 more source

HPLC estimation of iothalamate to measure glomerular filtration rate in humans [PDF]

, 2016
Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and urine.
Ashraf, Syed Salman, Barker, James, Barton, Stephen J., Naughton, Declan P., Shah, Iltaf   +4 more
core   +1 more source

Iberian pig adaptation to acorn consumption: I. Net portal appearance of metabolites [PDF]

PeerJ, 2018
Most valuable cured products from Iberian pigs come from pure bred animals raised for a final grazing-fattening period where pigs eat mainly acorns, a low protein energy rich fruit.
Ignacio Fernández-Fígares, Jose Miguel Rodríguez-López, Lucrecia González-Valero, Manuel Lachica   +3 more
doaj   +2 more sources

The synthesis of some acylglycines and related oxazolones [PDF]

, 1960
No description ...
Acheson, R M, Booth, D A, Brettle, R, Harris, A M   +3 more
core   +1 more source