Results 51 to 60 of about 2,429 (203)

Population Physiologically‐Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Yumi Cleary, Bhagwat Prasad, Kayode Ogungbenro, Michael Gertz, Aleksandra Galetin   +4 more
wiley   +1 more source

Measurement of renal cortex perfusion: A direct comparison of arterial spin labelling magnetic resonance imaging and [15O]H2O positron emission tomography

Magnetic Resonance in Medicine, Volume 94, Issue 6, Page 2537-2549, December 2025.
Abstract Purpose Reliable information about renal blood supply is important to understand kidney physiology and diseases. Arterial spin labeling MR (ASL‐MR) imaging and [15O]H2O positron emission tomography (PET) can noninvasively measure tissue perfusion but have never been directly compared.
Naja Enevold Olsen, Christian Østergaard Mariager, Maibritt Meldgaard Arildsen, Sebastian Nielsen, Mikkel Holm Vendelbo, Michael Pedersen, Christoffer Laustsen, Steffen Ringgaard, Lars Poulsen Tolbod, Niels Henrik Buus   +9 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Urinary Metabolic Biomarkers of Attentional Control in Children With Attention‐Deficit/Hyperactivity Disorder: A Dimensional Approach Through 1H NMR‐Based Metabolomics

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
This study identified five attentional control subgroups in school‐aged children, with and without ADHD, using VR‐based behavioral tests. NMR metabolomics revealed subgroup‐specific urinary metabolic profiles linked to energy and amino acid metabolism.
Ana del Mar Salmerón, Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Francisco Manuel Arrabal‐Campos, Ana Cristina Abreu, Ignacio Fernández, Pilar Flores   +6 more
wiley   +1 more source

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast

, 2015
The organic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are expressed in the basal membrane of the placental syncytiotrophoblast.
Brooks, S., Cleal, J., Hanson, M., Lewis, R., Lofthouse, Emma, O'Kelly, Ita, Poore, K.   +6 more
core   +1 more source

Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model

Frontiers in Pharmacology, 2019
Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties of ...
Joske Millecam, Thomas van Bergen, Stijn Schauvliege, Gunther Antonissen, Ann Martens, Koen Chiers, Ronette Gehring, Elke Gasthuys, Johan Vande Walle, Siska Croubels, Mathias Devreese   +10 more
doaj   +1 more source

Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis [PDF]

, 2016
CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors determine plasma CCN-2 levels.
Bovenschen, N. (N.), Gerritsen, K.G. (Karin), Goldschmeding, R. (Roel), Joles, J.A. (Jaap), Koeners, M.P. (Maarten), Kok, R.J. (Robbert), Nguyen, T.Q. (Tri), Sprengers, D. (Dave), van Koppen, A.N.   +8 more
core   +6 more sources

Effects of patent foramen ovale in migraine: a metabolomics‐based study

The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.
Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong, Xin Li, Lu Zhang, Ge Liang, Wen Zheng, Luolan Gui, Shuming Ji, Yusha Tang, Hua Li, Wanling Li, Ruiqi Yang, Yajiao Li, Anjiao Peng, Yucheng Chen, Meng Gong, Lei Chen   +15 more
wiley   +1 more source

Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11) [PDF]

, 2013
Active components of complementary/alternative medicines and natural supplements are often anionic compounds and flavonoids. As such, organic anion transporters (OATs) may play a key role in their pharmacokinetic and pharmacological profiles, and ...
Sweet, Douglas H., Wang, Li
core   +3 more sources

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs

Physiological Reports, Volume 13, Issue 1, January 2025.
Abstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Ryan Morse, Gabriella A. M. Ten Have, John J. Thaden, Marielle P. K. J. Engelen, Sarah Rice, Martin Hagve, Nicolaas E. P. Deutz   +6 more
wiley   +1 more source