Results 61 to 70 of about 1,406 (193)

Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model

Frontiers in Pharmacology, 2019
Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties of ...
Joske Millecam, Thomas van Bergen, Stijn Schauvliege, Gunther Antonissen, Ann Martens, Koen Chiers, Ronette Gehring, Elke Gasthuys, Johan Vande Walle, Siska Croubels, Mathias Devreese   +10 more
doaj   +1 more source

Effects of patent foramen ovale in migraine: a metabolomics‐based study

The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.
Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong, Xin Li, Lu Zhang, Ge Liang, Wen Zheng, Luolan Gui, Shuming Ji, Yusha Tang, Hua Li, Wanling Li, Ruiqi Yang, Yajiao Li, Anjiao Peng, Yucheng Chen, Meng Gong, Lei Chen   +15 more
wiley   +1 more source

Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis [PDF]

, 2016
CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors determine plasma CCN-2 levels.
Bovenschen, N. (N.), Gerritsen, K.G. (Karin), Goldschmeding, R. (Roel), Joles, J.A. (Jaap), Koeners, M.P. (Maarten), Kok, R.J. (Robbert), Nguyen, T.Q. (Tri), Sprengers, D. (Dave), van Koppen, A.N.   +8 more
core   +6 more sources

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs

Physiological Reports, Volume 13, Issue 1, January 2025.
Abstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Ryan Morse, Gabriella A. M. Ten Have, John J. Thaden, Marielle P. K. J. Engelen, Sarah Rice, Martin Hagve, Nicolaas E. P. Deutz   +6 more
wiley   +1 more source

Screening study of hydroxytyrosol metabolites from in vitro fecal fermentation and their interaction with intestinal barrier repair receptor AhR

Journal of Food Science, Volume 89, Issue 12, Page 10134-10151, December 2024.
Abstract Olive oil polyphenol hydroxytyrosol (HT) significantly repairs intestinal barrier function, but its absorption in the stomach and small intestine is limited. The metabolites of unabsorbed HT that reach the colon are crucial, yet their effects on colonic microbiota and intestinal barrier repair remain unclear.
Yuqing Song, Mengting Li, Jingle Liu, Juan Wang, Aimei Zhou, Yong Cao, Shan Duan, Qun Wang   +7 more
wiley   +1 more source

Relationship of Thyroid Function with Renal Hemodynamics and Cholesterol Metabolism in Proteinuric Kidney Disease: A Pilot Study

Metabolites
Nephrotic syndrome and hypothyroidism are respectively reported to influence renal hemodynamics and hypercholesterolemia. However, the relationship of proteinuria-associated thyroid function with renal hemodynamics and cholesterol metabolism has yet to ...
Yoshitaka Iwazu, Kazuhiko Kotani, Taro Sugase, Daisuke Nagata, Toshiyuki Yamada   +4 more
doaj   +1 more source

Blood L‐cystine levels positively related to increased risk of hypertension

The Journal of Clinical Hypertension, Volume 26, Issue 12, Page 1411-1423, December 2024.
Abstract Hypertension is one component of metabolic syndrome (MetS). Here, the study evaluated hypertension‐associated metabolites in relation to other MetS components. Fasting plasma samples were collected from 22 hypertensive and 63 normotensive subjects for non‐targeted metabolomics.
Haijun Chen, Yalan Deng, Hailing Zhou, Wenzhong Wu, Jinhua Bao, Deyou Cao, Yuze Li, Yingmei Feng   +7 more
wiley   +1 more source

Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo [PDF]

, 2014
BACKGROUND: Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration of herbal extracts that modulate
Eun Nam Kim, Hee Eun Kang, Hye Suk Lee, Hyeon-Uk Jeong, Im-Sook Song, Miwon Son, Sang-Zin Choi, Soon-Sang Kwon, Tae Yeon Kong   +8 more
core   +1 more source

The Development of a Direct Homologous Radioimmunoassay for Serum Cortisol [PDF]

, 1981
Peer ...
Giesemann, G., Müller, O. A., Scriba, Peter Christian, Stalla, G., Wood, W. G.   +4 more
core   +2 more sources

Use of Living Donors in Kidney Transplantation in Man [PDF]

, 1970
A series is presented of 238 living renal donors who have been followed for periods of from eight months to eight years. Careful selection of donors is mandatory in order to avoid postoperative mortality or morbidity. Anatomic variations which may affect
Halgrimson, CG, Ogden, D, Penn, I, Starzl, TE   +3 more
core   +1 more source