Early detection of ketoprofen-induced acute kidney injury in sheep as determined by evaluation of urinary enzyme activities [PDF]
, 2010 Peer ...
Honkavaara, Matti Juhana +9 more
core +1 more source
Frontiers in Pharmacology, 2019 Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties of ...
Joske Millecam +10 more
doaj +1 more source
Chemical assay of p-aminohippuric acid simplified by use of dimethylaminocinnamaldehyde in ethanol.
Clinical Chemistry, 1988 Abstract We have developed a new and simple method of p-aminohippuric acid determination by use of dimethylaminocinnamaldehyde (DACA). It differs from previous methods using DACA in that the reaction is carried out in ethanol rather than in dilute acid. This results in deeper and more stable color development.
Lewis B. Schwartz +2 more
openaire +3 more sources
The change of p-aminohippuric acid disposition kinetics accompanied by growth in mice.
Journal of Pharmacobio-Dynamics, 1985 The change of disposition kinetics for p-aminohippuric acid (PAH) was studied following intravenous administration of p-[glycyl-1-14C]aminohippuric acid to 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. The expiratory excretion of 14CO2 in 24 h following the administration was almost negligible in 1-day-old and 1-week-old mice in contrast to 3 ...
Junji Hirate +3 more
openaire +4 more sources
, 2015 The organic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are expressed in the basal membrane of the placental syncytiotrophoblast.
Brooks, S. +6 more
core +1 more source
Geometric-algebraic approach to aqueous solutions of diprotic acids and its buffer mixtures [PDF]
arXiv, 2023 A closed-form analytical expression for $\ce{[H3O+]}$ has been obtained for aqueous solutions of diprotic acids and its soluble salts. This formula allows to calculate the pH of aqueous solutions of diprotic acids, their buffer solutions, and the titrations of these two by a strong base, from the values of p$K_1$, p$K_2$, and the effective ...
arxiv
Large presence of carbonic acid in CO$_2$-rich aqueous fluids under Earth's mantle conditions [PDF]
Journal of Physical Chemistry Letters 10, 5135-5141 (2019), 2019 The chemistry of carbon in aqueous fluids at extreme pressure and temperature conditions is of great importance to Earth's deep carbon cycle, which substantially affects the carbon budget at Earth's surface and global climate change. At ambient conditions, the concentration of carbonic acid in water is negligible, so aqueous carbonic acid was simply ...
arxiv +1 more source
Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]
, 2017 Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska +8 more
core +3 more sources
Carbon Doping of MgB2 by Toluene and Malic-Acid-in-Toluene [PDF]
, 2010 The decomposition of malic acid in the presence of Mg and B was studied using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) which revealed that malic acid reacted with Mg but not B. Also, the addition of toluene to dissolve malic acid followed by subsequent drying resulted in no reaction with Mg, indicating that the malic
arxiv +1 more source
Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced qacute renal failure [PDF]
, 2007 The effect of acute renal failure (ARF) induced by ischemia/reperfusion (I/R) of rat kidney on the expression of organic anion transporters (OATs) was examined.
Hamada, A. +9 more
core +1 more source