Results 311 to 320 of about 645,423 (346)

GW/P-Bodies and Autoimmune Disease

2012
Human autoantibodies have performed admirably in the service of characterizing GW/P-bodies. These antibodies have provided a critical point of reference by which other proteins have been shown to be components of GW/P-bodies. In addition,autoantibodies have been used to identify new GW/P-body components, including Ge-l, GW182, RAP55, and YB-1.
Donald B, Bloch, Rita A, Nobre, Wei-Hong, Yang   +2 more
openaire   +2 more sources

The Discovery and Analysis of P Bodies

2012
The last decade has seen the discovery of a conserved class of cytoplasmic mRNP (messenger Ribonucleic Acid—Protein complexes) aggregates called Processing Bodies or P Bodies (Sheth and Parker 2003). They belong to a growing list of cytoplasmic mRNP aggregates, many of which are compositionally similar to P Bodies and consist of a host of translational
Saumya, Jain, Roy, Parker
openaire   +2 more sources

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage

Trends in Genetics, 2018
P-bodies (PBs) are cytosolic RNP granules that are conserved among eukaryotic organisms. In the past few years, major progress has been made in understanding the biochemical and biophysical mechanisms that lead to their formation. However, whether they play a role in mRNA storage or decay remains actively debated.
Weil, Dominique, Standart, Nancy
openaire   +3 more sources

P-bodies and mitochondria: Which place in RNA interference?

Biochimie, 2012
Micro-RNAs (miRNAs) are major actors of RNA interference (RNAi), a regulation pathway which leads to translational repression and/or degradation of specific mRNAs. They provide target specificity by incorporating into the RISC complex and guiding its binding to mRNA. Since the discovery of RNAi, many progresses have been made on the mechanism of action
Ernoult-Lange, Michèle, Bénard, Marianne, Kress, Michel, Weil, Dominique   +3 more
openaire   +3 more sources

RNAi and the P-body connection

Nature Cell Biology, 2005
Cytoplasmic processing bodies, also known as P-bodies, concentrate enzymes that are involved in mRNA turnover and sequester mRNAs away from the translational machinery. Strong evidence now connects the RNA interference machinery with P-body formation.
openaire   +1 more source

EDC4 C-terminal domain scaffolds P-body assembly and links P-body dynamics to p53-mediated tumor suppression

RNA
Processing bodies (P-bodies) are membraneless organelles in eukaryotic cells that play a central role in mRNA metabolism, including mRNA decay, storage, and translational repression. However, the molecular mechanisms governing their assembly remain incompletely understood.
Yu-Hsuan Cheng, Ting-Wen Chen, Wei-Chung Chiang, Jean-Cheng Kuo, Yi-Sheng Ho, Michelle Noble, Chung-Te Chang   +6 more
openaire   +3 more sources

P bodies get viscous

Nature Cell Biology, 2021
openaire   +2 more sources

P Bodies and mRNA Cycle

2013
Ökaryotik hücrelerin gen ekspresyonunda translasyonun kontrolü ve mRNA yıkımı önemli bir role sahiptir. P cisimcikleri mRNA moleküllerinin depolandığı, yıkıma uğratıldığı translasyonel olarak baskı altında tutulduğu ve RNAi aracılı susturmanın yapıldığı sitoplazmik oluşumlardır.
GÜRKÖK, Tuğba, BOZTEPE, Gülşen, KOYUNCU, Mesut, PARMAKSIZ, İskender   +3 more
openaire   +1 more source

Analyzing P-Bodies and Stress Granules in Saccharomyces cerevisiae

2010
Eukaryotic cells contain at least two types of cytoplasmic RNA-protein (RNP) granules that contain nontranslating mRNAs. One such RNP granule is a P-body, which contains translationally inactive mRNAs and proteins involved in mRNA degradation and translation repression.
J Ross, Buchan, Tracy, Nissan, Roy, Parker   +2 more
openaire   +2 more sources

Analyzing P-bodies in Saccharomyces cerevisiae.

Methods in enzymology, 2009
Cytoplasmic processing bodies, or P-bodies, are RNA-protein granules found in eukaryotic cells. P-bodies contain non-translating mRNAs and proteins involved in mRNA degradation and translational repression. P-bodies, and the mRNPs within them, have been implicated in mRNA storage, mRNA degradation, and translational repression.
Tracy, Nissan, Roy, Parker
openaire   +1 more source