Results 281 to 290 of about 20,489,060 (330)
Some of the next articles are maybe not open access.
Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives.
European Journal of Medicinal Chemistry, 2015With an aim to generate non-toxic, specific and highly potent multidrug resistance (MDR) modulators, a novel series of anthranilic acid amide-substituted tariquidar derivatives were synthesized. The new compounds were evaluated for their cytotoxicity toward normal human colon fibroblasts (CCD18-Co), human gastric epithelial cell line (HFE) and primary ...
Xu-Qin Li +6 more
semanticscholar +3 more sources
AAPS PharmSciTech, 2022
Significant research efforts have been devoted to unraveling the mystery of P-glycoprotein(P-gp) in drug delivery applications. The efflux membrane transporter P-gp is widely distributed in the body and accountable for restricting drug absorption and ...
Sachin Rathod +3 more
semanticscholar +1 more source
Significant research efforts have been devoted to unraveling the mystery of P-glycoprotein(P-gp) in drug delivery applications. The efflux membrane transporter P-gp is widely distributed in the body and accountable for restricting drug absorption and ...
Sachin Rathod +3 more
semanticscholar +1 more source
International Immunopharmacology, 2021
BACKGROUND Programmed cell death receptor 1 (PD-1) is an immunosuppressive molecule expressed on T cells, and its ligand (PD-L1) which expressed on tumor cells play pivotal roles in regulating host immune responses.
Lijun Wu +6 more
semanticscholar +1 more source
BACKGROUND Programmed cell death receptor 1 (PD-1) is an immunosuppressive molecule expressed on T cells, and its ligand (PD-L1) which expressed on tumor cells play pivotal roles in regulating host immune responses.
Lijun Wu +6 more
semanticscholar +1 more source
Medicinal research reviews (Print), 2020
Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP‐binding cassette (ABC) transporter superfamily is considered one of the primary ...
Hang Zhang +5 more
semanticscholar +1 more source
Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP‐binding cassette (ABC) transporter superfamily is considered one of the primary ...
Hang Zhang +5 more
semanticscholar +1 more source
Modulation of P-gp expression by lapatinib
Investigational New Drugs, 2010Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps, such as P-glycoprotein (P-gp). Lapatinib, a growth factor receptor tyrosine kinase inhibitor, is currently in clinical trials for treatment of breast cancer.
Gráinne, Dunne +5 more
openaire +2 more sources
Dietary regulation of P-gp function and expression
Expert Opinion on Drug Metabolism & Toxicology, 2009Food-drug interactions have been associated with clinically important pharmacokinetic and pharmacodynamic changes of a drug. The aim of this paper is to review the regulation of P-glycoprotein (P-gp) by dietary components and to correlate the changes in cellular P-gp function and expression with drug bioavailability.
Wenxia, Zhang +3 more
openaire +2 more sources
Generalisation of GPS and P-GPS in network calculus
2012 9th IEEE International Workshop on Factory Communication Systems, 2012GPS is an ideal well known policy designed to share the capacity of a server between the input flows: each flow receives a fractional part, defined by the administrator, of the total server capacity1. It has several practical implementations, like P-GPS. These policies have been defined in the context of a constant-rate server.
William Mangoua Sofack, Marc Boyer
openaire +1 more source
Recent Advances in the Development of P-gp Inhibitors
Anti-Cancer Agents in Medicinal Chemistry, 2009During the last decades multidrug resistance (MDR) emerged as main problem in the anti-cancer therapy with cytostatically active agents. Classical as well as recently developed cytostatics develop the phenomenon of loosing activity in former drug-sensitive cells.
Christiane, Baumert, Andreas, Hilgeroth
openaire +2 more sources
TGF‐β1 elevates P‐gp and BCRP in hepatocellular carcinoma through HOTAIR/miR‐145 axis
Biopharmaceutics & drug disposition, 2019Multidrug resistance (MDR) is common in patients and has been linked to transforming growth factor‐β1 (TGF‐β1) and overexpression of drug efflux transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP), although the molecular ...
Jiehong Kong +4 more
semanticscholar +1 more source
Drug Discovery Today
Drug resistance has compromised the efficacy of chemotherapy. The dysregulation of drug transporters including P-glycoprotein (P-gp) can mediate drug resistance through drug efflux.
Yang Guo +5 more
semanticscholar +1 more source
Drug resistance has compromised the efficacy of chemotherapy. The dysregulation of drug transporters including P-glycoprotein (P-gp) can mediate drug resistance through drug efflux.
Yang Guo +5 more
semanticscholar +1 more source