Results 291 to 300 of about 20,489,060 (330)
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Drug-Drug Interactions of P-gp Substrates Unrelated to CYP Metabolism.
Current drug metabolism, 2019BACKGROUND Recent US Food and Drug Administration (FDA) draft guidance on pharmacokinetic drugdrug interactions (DDIs) has highlighted the clinical importance of ABC transporters B1 or P-glycoprotein (P-gp), hepatic organic anion-transporting polypeptide
Y. Akamine, N. Yasui-Furukori, T. Uno
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A porcine lymphocyte model for P‐gp inhibition studies
Journal of Veterinary Pharmacology and Therapeutics, 2011Short ...
Schrickx, J.A., Fink-Gremmels, J.
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Journal of Molecular Modeling, 2012
P-glycoprotein (P-gp) has a major role to play in drug pharmacokinetics and pharmacodynamics, since it effluxes many cytotoxic hydrophobic anticancer drugs from gastrointestinal tract, brain, liver and kidney. Piperine is known to enhance the bioavailability of curcumin, as a substrate of P-gp by at least 2000%.
Durg Vijay, Singh +2 more
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P-glycoprotein (P-gp) has a major role to play in drug pharmacokinetics and pharmacodynamics, since it effluxes many cytotoxic hydrophobic anticancer drugs from gastrointestinal tract, brain, liver and kidney. Piperine is known to enhance the bioavailability of curcumin, as a substrate of P-gp by at least 2000%.
Durg Vijay, Singh +2 more
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Pharmaceutical Research, 2004
To determine whether female sex-steroid hormones and their metabolites can modulate P-glycoprotein (P-gp) expression and catalytic activity and to investigate P-gp mediated transport of these sex-steroids across MDR1-transfected Madine-Darby canine kidney (MDCK) cells.Changes in P-gp protein and MDR1 mRNA expression levels were examined in the presence
Winnie Y, Kim, Leslie Z, Benet
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To determine whether female sex-steroid hormones and their metabolites can modulate P-glycoprotein (P-gp) expression and catalytic activity and to investigate P-gp mediated transport of these sex-steroids across MDR1-transfected Madine-Darby canine kidney (MDCK) cells.Changes in P-gp protein and MDR1 mRNA expression levels were examined in the presence
Winnie Y, Kim, Leslie Z, Benet
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Pharmaceutical Research, 2023
The differences between intestinal and systemic (hepatic and renal) P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) roles in drug disposition are difficult to define. Accordingly, we characterized Encequidar (ECD) as an intestinal P-gp and BCRP specific inhibitor to evaluate their role in drug disposition.We assessed the in vitro and ...
Jessica Chu +12 more
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The differences between intestinal and systemic (hepatic and renal) P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) roles in drug disposition are difficult to define. Accordingly, we characterized Encequidar (ECD) as an intestinal P-gp and BCRP specific inhibitor to evaluate their role in drug disposition.We assessed the in vitro and ...
Jessica Chu +12 more
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P-gp Transporter and its Role in Neurodegenerative Diseases
Current Topics in Medicinal Chemistry, 2009This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) and Creutzfeldt-Jakob's (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy.
RAPPOSELLI, SIMONA +2 more
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Importance of P-gp PET Imaging in Pharmacology
Current Pharmaceutical Design, 2016Capillary endothelial cells in the brain express P-glycoprotein (P-gp), which works as a functional blood-brain barrier (BBB). P-gp pumps out multiple types of molecules from the brain parenchyma into the blood. Therefore, altered P-gp function at the BBB will change the concentrations of therapeutic drugs in the central nervous system (CNS) and hence ...
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A New Method to Measure P-gp (ABCB1) Activity
Drug Metabolism Letters, 2007We have developed an easy and sensitive method to measure P-glycoprotein (P-gp) activity using [gamma-(32)P]ATP and charcoal. This method utilizes the nature of adsorption of organic phosphate to charcoal. The standard assay method is as follows: the reaction mixture (20 microl) of 1 mM [gamma-(32)P]ATP (1 Ci/mol), 2.5 microg P-gp membranes, and the ...
Masatoshi, Masuda, Takaharu, Mizutani
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European journal of medicinal chemistry, 2018
P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) is a well-documented and predominant phenotype hampering patients' response to cancer chemotherapy.
Xiaodong Ma +3 more
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P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) is a well-documented and predominant phenotype hampering patients' response to cancer chemotherapy.
Xiaodong Ma +3 more
semanticscholar +1 more source
Effect of berberine on the pharmacokinetics of substrates of CYP3A and P‐gp
Phytotherapy Research, 2009AbstractThein vivoeffects of berberine (BBR), the widely used bioactive herbal ingredient from many traditional Chinese medicinal herbs, on the pharmacokinetics of carbamazepine (CBZ, a substrate of CYP3A) and its metabolite carbamazepine 10,11‐epoxide (ECBZ), digoxin (DIG, a substrate of P‐gp) and cyclosporine A (CsA, a dual substrate of CYP3A and P ...
W, Qiu +4 more
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