Results 201 to 210 of about 36,100 (302)

Novel Diffuse Midline Glioma‐on‐Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies

open access: yesSmall, EarlyView.
In this work, a DMG‐on‐Chip (DoC) is set up, with a geometry yielding gradients of nutrient and oxygen depletion, to recapitulate this trait of tumor microenvironment‐driven heterogeneity. The biophysical and biochemical characterization of this microsystem via fluorescence microscopy analyses highlights the acidification of the tumor core, along with ...
Lisa Terrassoux   +17 more
wiley   +1 more source

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

open access: yesSmall Methods, EarlyView.
This study describes the development and applications of a transgenic lamin‐based senescence reporter platform based on changes in lamin‐B1‐ and lamin‐A intensities during senescence‐induction. The reporter platform is a versatile tool, allowing to screen for and sort senescent cancer cells, allowing marker integration (for example incorporating IL6 ...
Jacinta van de Grint   +10 more
wiley   +1 more source

Design, Fabrication, Mechanics, and Multifunctional Applications of Shell‐Based Nanoarchitected Materials

open access: yesSmall Structures, EarlyView.
Shell‐based nanoarchitected materials feature continuous surfaces, nanoscale feature sizes, and strong constituent materials, and exhibit high modulus/strength, remarkable recoverability, and substantial energy absorption capacity. This review provides an overview of recent progresses in shell‐based nanoarchitected materials from the perspectives of ...
Hanzheng Xing   +9 more
wiley   +1 more source

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