Results 91 to 100 of about 1,752,237 (247)

T-cell-replete haploidentical transplantation versus autologous stem cell transplantation in adult acute leukemia: a matched pair analysis

Haematologica, 2015
Adult patients with acute leukemia in need of a transplant but without a genoidentical donor are usually considered upfront for transplantation with stem cells from any other allogeneic source, rather than autologous stem cell transplantation.
Norbert-Claude Gorin, Myriam Labopin, Simona Piemontese, William Arcese, Stella Santarone, He Huang, Giovanna Meloni, Felicetto Ferrara, Dietrich Beelen, Miguel Sanz, Andrea Bacigalupo, Fabio Ciceri, Audrey Mailhol, Arnon Nagler, Mohamad Mohty   +14 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Satisfaction of Shahid Sadoughi University of Medical Sciences\' alumni about the quality of medical education

Journal of Medical Education and Development, 2013
Introduction: In order to achieve acceptable quality in educations, the quality of learning should be assessed. opinion of alumni in assessment of the quality of education is important, This study aims to assess the quality of medical education in basic ...
S.J. Mirmohammadi, A. H. Mehrparvar, M. Bahaloo, M. H. Davari   +3 more
doaj  

Mídia televisiva e sua influência no estilo de vida dos telespectadores do programa Vida e Saúde

RECIIS
O objetivo deste estudo foi analisar o estilo de vida de telespectadores do programa Vida e Saúde, da TV Novo Tempo, e sua relação com a saúde física, mental e sua qualidade de vida.
Danilo André de Souza Rosa, Eliane Teruel Gouveia Teixeira, Maria Dyrce Dias Meira, Aline Borburema Neves Veloso, Gina Andrade Abdala   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Sportmedizin im Wandel

Deutsche Zeitschrift für Sportmedizin, 2017
Objective: Assessment of heart rate variability (HRV) is increasingly used to evaluate dynamic features of cardiovascular (cv) control mechanisms and offers a unique insight into autonomic cv modulation in health and diseases.
Ketelhut SR, Ketelhut S, Riedel S, Willich S, Meyer-Sabellek W, Müssig K, 5, 6, Ketelhut K   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effects of 12-week integrative neuromuscular training on muscular fitness and sex differences in response to intervention in five- to six-year-old preschoolers [PDF]

PeerJ
Objectives This study examined the effects of a 12-week integrative neuromuscular training (INT) program on muscular fitness in male and female five- to six-year-old preschoolers.
Zhihai Wang, Jiayu Zang, Zhaohong Wang, Daniel T.P. Fong, Dan Wang   +4 more
doaj   +2 more sources