Results 201 to 210 of about 43,193,860 (312)

Elucidation of key lactylation- and palmitoylation-related genes and their related mechanisms in the development of neuropathic pain. [PDF]

Medicine (Baltimore)
Yan H, Li L, Li J, Hao J, Yang Y.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Transition from laparoscopic to robotic hepatectomy within a minimally invasive liver surgery program: risk-adjusted learning curve assessment by multiple continuous outcomes. [PDF]

J Robot Surg
Bernardi L, Garosi E, Roesel R, Mongelli F, Hunjan I, Sitta V, Majno-Hurst P, Cristaudi A.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Development and Validation of a Nomogram for Predicting Recurrence in Patients Previously Treated Conservatively for Cervical Spondylosis. [PDF]

Int J Gen Med
Mao H, Lu G, Zhou S, Zhuang M, Xiu X, Li J, Sun X, Liu Y, Ma M, Hu J, Yu J, Zhu L.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Loss of Chromosome Y and Risk of Abdominal Aortic Aneurysm.

JAMA Cardiol
Nordan T, Bellomo TR, Uddin MM, Xue L, Cho SMJ, Paruchuri K, Billaud M, Libby P, Natarajan P, Nakao T.   +9 more
europepmc   +1 more source

Development of a predictive model and nomogram using CTPA parameters for the identification of group 1 pulmonary arterial hypertension. [PDF]

iScience
Yuan H, Cheang I, Liang G, Zhu X, Xing Y, Li W, Liao S, He J, Cao Y, Li X, Xu Y, Zhou Y.   +11 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Deconstructing Risk: A Machine Learning-Guided Logistic Regression Model for Predicting Early Mucosal Edema Following Prophylactic Ileostomy in Elderly Rectal Cancer Patients. [PDF]

Int J Gen Med
Zeng Y, Bao L, Li J, Hong Y.
europepmc   +1 more source