Results 41 to 50 of about 171,284 (274)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann +23 more
wiley +2 more sources
Frontiers in Microbiology, 2018 Ferulic acid (FA) and p-hydroxybenzoic acid (PHBA) are main phenolic compounds accumulated in rhizosphere of continuously cropped cucumber, causing stress in plants. Microbial degradation of a mixture of FA and PHBA is not well understood in soil.
Fenghui Wu +10 more
doaj +1 more source
Explicit birational geometry of 3-folds of general type, I [PDF]
, 2009 Let $V$ be a complex nonsingular projective 3-fold of general type. We prove $P_{12}(V):=\text{dim} H^0(V, 12K_V)>0$ and $P_{m_0}(V)>1$ for some positive integer $m_0\leq 24$. A direct consequence is the birationality of the pluricanonical map $\varphi_m$
Chen, Jungkai A., Chen, Meng
core +2 more sources
Advanced Engineering Materials, EarlyView.The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi +3 more
wiley +1 more source
Frontiers in Neurology, 2011 The P13 potential is the rodent equivalent of the P50 potential, which is an evoked response recorded at the vertex (Vx) 50 msec following an auditory stimulus in humans.
Christen eSimon +4 more
doaj +1 more source
Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results [PDF]
, 2017 Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory diseases. The advent of biosimilar treatment options such as CT-P13 promises to improve the availability of biological therapy,
Argüelles Arias, Federico +7 more
core
Pi N -> Omega N in a Coupled-Channel Approach
, 2001 We describe the pi N -> omega N cross section from threshold to a center of mass energy of 2 GeV in a unitary coupled-channel model and analyze it in terms of rescattering and resonance excitations.
Mosel, U., Penner, G.
core +1 more source
Advanced Materials Technologies, EarlyView.An all‐in‐one microfluidic platform consists of two‐layered PDMS channels integrated with a hydrogel microwell array. This platform enables flow‐driven tumor cell capture, enhanced spheroid formation within the microwells, and advective drug testing. ABSTRACT Effective cancer drug screening requires platforms that replicate the physiological complexity
Omar M. Rahman +2 more
wiley +1 more source