黄芪甲苷通过抑制STING通路减轻D-半乳糖诱导的心肌细胞衰老和凋亡
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨黄芪甲苷（AS-Ⅳ）对D-半乳糖（D-gal）诱导的心肌细胞衰老的保护作用及其潜在机制。方法以心肌细胞H9C2为模型，采用D-gal诱导心肌细胞衰老，通过CCK-8法检测细胞活力，β-半乳糖苷酶（SA-β-Gal）染色评估细胞衰老程度，ROS检测细胞内活性氧水平，TUNEL检测细胞凋亡程度，qRT-PCR和Western blot检测衰老相关基因和蛋白（p21、p53）及干扰素基因刺激因子（STING）通路关键基因（STING、CXCL10和 MX-1）和蛋白（STING、cGAS、p-IRF3/
郭文玉 +6 more
doaj
微流控芯片检测肺癌患者血浆中P16基因异常甲基化在临床应用的评价
肺癌是常见的恶性肿瘤之一，其死亡率和发病率在世界范围的肿瘤性疾病中均居高不下．p16基因启动子区异常甲基化被认为是肺癌发生中的一起早期事件．为了提高检测异常甲基化方法的灵敏度及特异性．利用微流控芯片检测p16基因的异常甲基化．通过对肺癌患者血浆标本的检测，使病人血浆中的p16基因甲基化的异常改变可能成为辅助肺癌早期诊断和高危人群筛选的分子标记物 ...
周小棉 +5 more
core
[Research advances on the role of cell senescence in chronic wound healing]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2023 Fang SYH, Liu DW.
europepmc +1 more source
[Research Progress in Stress-Induced Senescence of Renal Tubular Cells in Diabetic Nephropathy]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Yi X, He Y, Chen K.
europepmc +1 more source
[Effect and mechanism of astaxanthin on the aging of high glucose-treated human skin fibroblasts]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiTang LJ +6 more
europepmc +1 more source
[Research progress in diagnosis and treatment of HPV-associated oropharyngeal squamous cell carcinoma]. [PDF]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2023 He M, Yi J.
europepmc +1 more source
[Clinicopathological Characteristics of Cervical Neuroendocrine Carcinoma and Their Relationship With Prognosis]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLan T +7 more
europepmc +1 more source
[Clinicopathological analysis of mesonephric-like adenocarcinoma in the corpusuteri: A report of 3 cases]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanWang X, Li L, Zhang W, Wang H.
europepmc +1 more source
[Acute myeloid leukemia (M(3)) with multiple myeloma: a case report]. [PDF]
Zhonghua Xue Ye Xue Za Zhi, 2023 Yan B +6 more
europepmc +1 more source
[<i>Buyang Huanwu</i> Decoction delays vascular aging in rats through exosomal miR-590-5p signal-mediated macrophage polarization]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoTu S, Chen X, Li C, Huang D, Zhang L.
europepmc +1 more source