Results 231 to 240 of about 99,821 (298)

Perturbation‐induced responses improved seizure forecasting in epileptic rats

Epilepsia, EarlyView.
Abstract Objective The unpredictability of seizures is one of the most challenging aspects of uncontrolled epilepsy for patients. Prior work forecasting seizure risk has measured changes in passive intracranial electroencephalographic (EEG) signals, but currently, there are no such clinical devices available.
Wei‐Chih Chang, Jack Lin, Warwick Cheung, Alan Lai, Mark J. Cook, David B. Grayden, William C. Stacey   +6 more
wiley   +1 more source

Mortality in functional seizures: Evidence from a large electronic health records dataset

Epilepsia, EarlyView.
Abstract Objective Several studies have found that people with functional seizures (FS) have increased mortality, approaching that of epilepsy (epileptic seizures [ES]). The small numbers of deaths in these studies make it unclear whether they can be attributed to comorbidities. We used a very large electronic health database to compare mortality in FS
Richard A. Kanaan, Rok Berlot, Tom Pollak, Markus Reuber, Stoyan Popkirov   +4 more
wiley   +1 more source

Variants in human CD48 lead to impaired T cell immunity and increased inflammation. [PDF]

J Clin Invest
Milanesi S, Lorenzini T, Marchetti T, Tintor D, Planas R, Sabet O, Malmström L, Acharya S, Williams CD, Manning ZE, Roser JH, Ehler AC, Huber M, Prader S, Vavassori S, Dutmer CM, Abbott JK, Pachlopnik Schmid J.   +17 more
europepmc   +1 more source

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor. [PDF]

J Org Chem
Gregorc J, De Neve J, Guitot K, Holleran BJ, Lensen N, Gendron L, Brigaud T, Iskra J, Ballet S, Chaume G.   +9 more
europepmc   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Safety, effectiveness and treatment patterns of sodium zirconium cyclosilicate for hyperkalemia management in China: actualize study. [PDF]

Front Pharmacol
Shen N, Zeng X, Xie H, Zhang L, Yang J, Lin Y, Liu X, Cai X, Cao J, Zhu Q, Luo X, Wan X, Wu H, Ye J, Shan C, Wu Y, Cao Y, Lin Y, Yu X, Wang H, He J, Tian S, Wu F, Jiang X, Li L, Zuo L, Wang Z, Xing C, Yin X, Zhao J, Ma C, Long G, Li Q, Hu Y, Shi Y, Lin H.   +35 more
europepmc   +1 more source

Evaluation of the Adequacy of Design Specifications for Nonstructural Components in a Reticular Structure

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Nonstructural components (NSCs) installed in large‐span reticular structures were frequently severely damaged during earthquakes, even when the primary structure remained intact. Existing seismic design specifications for NSCs were predominantly developed for upright structures such as multi‐storey buildings and offer no guidance for reticular
Xudong Zhi, Fengze Li, Duozhi Wang, Nawawi Chouw, Rong Zhang, Bo Huang, Feng Fan   +6 more
wiley   +1 more source

Gut plasma membrane proteomes reflect the distinct feeding strategies of Nezara viridula and Diaphorina citri. [PDF]

Sci Rep
Mishra R, Arora AK, Jiménez J, Tavares CS, Bonning BC.   +4 more
europepmc   +1 more source

Sensitivity of 3D Base‐Isolated Buildings to Individual Isolator Variability

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Variability in elastomeric isolators arises from differences in rubber formulation and curing, leading to noticeable changes in stiffness and damping among nominally identical bearings. While most previous studies have examined global isolator variability associated with environmental or aging effects, individual isolator variability has ...
Norouz Jahan, Niel C. Van Engelen
wiley   +1 more source