Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore +7 more
wiley +1 more source
Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice. [PDF]
Bapat VA, Waters RC, Gordon JK, Gould E.
europepmc +1 more source
Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBγ Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways. [PDF]
Tran J +4 more
europepmc +1 more source
ABSTRACT Objective Quantitative methods that have evaluated the Eating Disorder Examination Questionnaire (EDE‐Q) have found consistent evidence that the original four‐factor structure does not replicate across diverse samples and genders. Emerging evidence in the broader psychology literature shows that qualitative methods can provide nuanced insight ...
Katarina L. Huellemann +3 more
wiley +1 more source
Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression. [PDF]
Hu Y +23 more
europepmc +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
The AKT-p21 phosphorylation signaling axis confers poor prognosis and dacarbazine resistance in melanoma. [PDF]
Colaneri GN +13 more
europepmc +1 more source
Synthesis, Crystal Structure, and Optoelectronic Properties of [(n‐/tert‐C4H9)S(CH3)2]PbI3
Reaction of two isomers of butyldimethylsulfonium cation with PbI2 using solid‐state and solution methods yielded the corresponding organic/inorganic hybrid compounds with high humidity tolerance and 1D crystal structures of [n‐C4H9S(CH3)2]PbI3 and [tert‐C4H9S(CH3)2]PbI3.
Ioannis Koutsoumpogeras +4 more
wiley +1 more source

