FOXO1 Inhibition and FADD Knockdown Have Opposing Effects on Anticancer Drug-Induced Cytotoxicity and p21 Expression in Osteosarcoma Cells. [PDF]
Int J Mol SciWalker D +5 more
europepmc +1 more source
European Journal of Inorganic Chemistry, EarlyView.The first low‐oxidation (I/III) state chromium‐complex bearing a O‐chelating NHC ligand has been synthesized and structurally characterized by single‐crystal X‐ray analysis. The formation of the mixed‐valence species was further supported by SQUID magnetometry and high‐field electron paramagnetic resonance (EPR) spectroscopy.
Somnath Bhattacharya +4 more
wiley +1 more source
17-β-Estradiol Protects Chondrocytes From Senescence and Ameliorates Osteoarthritis Progression via ERα-AKT-FOXO4 Pathway. [PDF]
J Cell Mol MedLiu Y +6 more
europepmc +1 more source
European Journal of Inorganic Chemistry, EarlyView.Two rubidium cations that are not fully encapsulated by 18‐crown‐6 are bridged by two pertechnetate units to form a dimer. These two pertechnetate units are nearly linearly aligned to each other to form Matere bonds (MaBs), a type of noncovalent σ‐hole interaction.
Clarence Yong +7 more
wiley +1 more source
Integrated bioinformatics analysis and experimental validation reveal Pevonedistat as a promising therapeutic agent modulating the CRL4-DTL-p21/p53 axis in nasopharyngeal carcinoma. [PDF]
HereditasJia CC, Li ZY, Jia WH, Jiang CT.
europepmc +1 more source
From Phosphinimines to Four‐Membered SiCPN Cations: Insights Into N–Si Bonding and Ring Strain
European Journal of Inorganic Chemistry, EarlyView.Sterically tuned N‐silyl phosphinimines enable four‐membered SiCPN cations. Hydride abstraction yields cyclic cations for Me and iPr substituents at silicon, while tBu gives a protonated intermediate. Multinuclear NMR spectroscopy, X‐ray crystallography, thermochemical density functional theory investigations, and natural bond orbital analyses reveal ...
Alexander Falk, Jonathan O. Bauer
wiley +1 more source
Synthesis of Novel C‐Acyl‐Glycosyl Sulfonamides via Pd‐Catalyzed Carbonylative Coupling
European Journal of Organic Chemistry, EarlyView.A Pd‐catalyzed carbonylative coupling of 1‐iodo‐glycals with diverse sulfonamides using Mo(CO)6 enables efficient access to C‐acyl‐glycosyl sulfonamides.This robust and versatile strategy delivers novel glycoside derivatives in good to excellent yields, highlighting their potential for drug discovery.
João A. F. Silva +5 more
wiley +1 more source
Fisetin-Mediated Topical Modulation of Senescent Cells in Skin Improves Wound Healing Dynamics in Diabetic Mice. [PDF]
Adv Wound Care (New Rochelle)Numani A +6 more
europepmc +1 more source
Epilepsia, EarlyView.Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall +3 more
wiley +1 more source