Differential Expression of the Metabotropic P2Y Receptor Family in the Cortex Following Status Epilepticus and Neuroprotection via P2Y1 Antagonism in Mice [PDF]
Frontiers in Pharmacology, 2020 Purinergic signaling via P2 receptors is now widely accepted to play a critical role during increased states of hyperexcitability and seizure-induced pathology.
Mariana Alves +4 more
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Pharmacological characterization of P2Y receptor subtypes - an update. [PDF]
Purinergic Signal, 2023 P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14).
von Kügelgen I.
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Update of P2Y receptor pharmacology: IUPHAR Review 27. [PDF]
Br J Pharmacol, 2020 Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like GPCRs and contain two structurally distinct subfamilies: P2Y1, P2Y2, P2Y4 ...
Jacobson KA +13 more
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Pharmacological Nature of the Purinergic P2Y Receptor Subtypes That Participate in the Blood Pressure Changes Produced by ADPβS in Rats [PDF]
Pharmaceuticals, 2023 Purine nucleosides (adenosine) and nucleotides such as adenosine mono/di/triphosphate (AMP/ADP/ATP) may produce complex cardiovascular responses. For example, adenosine-5′-(β-thio)-diphosphate (ADPβS; a stable synthetic analogue of ADP) can induce ...
Roberto C. Silva-Velasco +4 more
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The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy. [PDF]
Front Pharmacol, 2018 Epilepsy encompasses a heterogeneous group of neurological syndromes which are characterized by recurrent seizures affecting over 60 million people worldwide.
Alves M, Beamer E, Engel T.
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P2Y receptor modulation of ATP release in the urothelium. [PDF]
Biomed Res Int, 2014 The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from
Mansfield KJ, Hughes JR.
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P2X and P2Y receptor signaling in red blood cells. [PDF]
Front Mol Biosci, 2015 Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Sluyter R.
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ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.
PLoS ONE, 2012 Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Recently, we demonstrated that P2Y(1) and P2Y(12) purinoceptor activities are
Venkateswarlu Kanamarlapudi +4 more
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Extracellular ATP Induced S-Phase Cell Cycle Arrest via P2Y Receptor-Activated ERK Signaling in Poorly Differentiated Oral Squamous Cell Carcinoma SAS Cells [PDF]
Life, 2021 Extracellular ATP in the tumor microenvironment exhibits either pro- or antitumor effect via interaction with P2Y receptors, but the intracellular signaling and functional roles of P2Y receptors in oral squamous cell carcinoma (OSCC) are unclear.
Chia Chih Lau +5 more
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
Respiratory Research, 2005 Background Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Gurney Alison M +2 more
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