Results 91 to 100 of about 2,327,568 (312)

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E., Peppiatt-Wildman, Claire M., Schwiebert, E. M., Wildman, Scott S.P.   +3 more
core   +2 more sources

Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury

Cell Transplantation, 2015
Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D., Francisco Javier Rodríguez-Jiménez, Ana Alastrue-Agudo, Miodrag Stojkovic, María Teresa Miras-Portugal, Victoria Moreno-Manzano   +5 more
doaj   +1 more source

Extracellular Ca2+ modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation

British Journal of Haematology, 2011
ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca2+ [(Ca2+)o].
Sarah Jones, R. Evans, M. Mahaut-Smith
semanticscholar   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

Glia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi, Dennis Lawrence Cheung, Junko Ishida, Junichi Nabekura   +3 more
wiley   +1 more source

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

BMC Cell Biology, 2005
Background Recent studies indicate that the G protein-coupled receptor (GPCR) signaling machinery can serve as a direct target of reactive oxygen species, including nitric oxide (NO) and S-nitrosothiols (RSNOs).
Mönkkönen Kati S, Savinainen Juha R, Kokkola Tarja, Retamal Montse, Laitinen Jarmo T   +4 more
doaj   +1 more source

ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. [PDF]

PLoS ONE, 2013
The respiratory epithelium is subject to continuous environmental stress and its responses to injury or infection are largely mediated by transactivation of the epidermal growth factor receptor (EGFR) and downstream signaling cascades.
Derek Sham, Umadevi V Wesley, Milena Hristova, Albert van der Vliet   +3 more
doaj   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Beyond the surface: P2Y receptor downstream pathways, TLR crosstalk and therapeutic implications for infection and autoimmunity

Pharmacological Research
A successful immune response must effectively obtain pathogen clearance upon infection while preventing excessive collateral tissue damage. It is therefore essential to achieve a nuanced fine regulation of pro- and anti-inflammatory signals to ...
Lena Rueschpler, Sebastian Schloer
doaj   +1 more source

Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

Molecular Pain, 2010
Background Investigations of nucleotide signaling in nociception to date have focused on actions of adenosine triphosphate (ATP). Both ATP-gated ion channels (P2X receptors) and G protein-coupled (P2Y) receptors contribute to nociceptive signaling in ...
Molliver Derek C, Malin Sacha A
doaj   +1 more source