Results 101 to 110 of about 2,327,568 (312)
Recommended tool compounds and drugs for blocking P2X and P2Y receptors [PDF]
, 2021 Christa E. Müller +1 more
openalex +1 more source
Journal of Biological Chemistry, 1999 In Madin-Darby canine kidney D1cells extracellular nucleotides activate P2Y receptors that couple to several signal transduction pathways, including stimulation of multiple phospholipases and adenylyl cyclase.
M. Xing +4 more
semanticscholar +1 more source
Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges
Advanced Science, Volume 13, Issue 5, 27 January 2026.This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li +7 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source
Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]
, 2009 Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke +5 more
core +1 more source
Functional Compartmentation of Endothelial P2Y Receptor Signaling [PDF]
Circulation Research, 2002 The presence of multiple receptors for disparate nucleotides on endothelial cells makes it unclear how the endothelium differentiates among these signals. We propose that endothelial P2Y receptors are organized into cholesterol-rich signaling domains, such as caveolae and respond to nucleotide agonists by mobilizing intracellular calcium.
Robert A, Kaiser +3 more
openaire +2 more sources
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Cell Proliferation, Volume 59, Issue 1, January 2026.Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng +4 more
wiley +1 more source
Sustained release of prostaglandin E2 in fibroblasts expressing ectopically cyclooxygenase 2 impairs P2Y-dependent Ca2+-mobilization [PDF]
, 1943 The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). P2Y receptors are G protein-coupled receptors expressed in many cell types.
Pimentel-Santillana, María +6 more
core +2 more sources
The Journal of Physiology, Volume 604, Issue 1, Page 379-394, 1 January 2026.Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera +8 more
wiley +1 more source
Expression analysis of G Protein-coupled receptors in mouse macrophages [PDF]
, 2008 Background. Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity.
Glass, Christopher K. +10 more
core +4 more sources