Results 111 to 120 of about 2,327,568 (312)

Satellite glial cell P2Y₁₂ receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats

Molecular Pain, 2012
Background It has been reported that the P2Y12 receptor (P2Y12R) is involved in satellite glial cells (SGCs) activation, indicating that P2Y12R expressed in SGCs may play functional roles in orofacial neuropathic pain mechanisms. However, the involvement
Katagiri Ayano, Shinoda Masamichi, Honda Kuniya, Toyofuku Akira, Sessle Barry J, Iwata Koichi   +5 more
doaj   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, Volume 9, Issue 12, December 2025.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz, BD Gill, C Crawford, Claire M. Peppiatt-Wildman, DR Ferguson, DR Schneider, EM Schwiebert, EW Inscho, EW Inscho, FQ Yang, G Burnstock, G Burnstock, G Burnstock, G Manfredi, G Xu, HA Neufeld, HA Praetorius, HA Praetorius, Hardyal S. Gill, HM Liebich, I Kugelgen von, I Kugelgen von, J Czarnecka, James Malone-Lee, JC Mathies, Jennifer C. Jacoby, JM Buescher, JO Svensson, JR Gever, K Sugaya, Kevin M. G. Taylor, KH Schram, KR Kim, LA Birder, LC Rump, LD Todorov, M Cichna, M Katayama, MA Bailey, N Ozer, N Yamaoka, NS Zur, P Bodin, P Vinas, PD Wilson, R Corriden, RC Calvert, Rebecca E. Birch, RL Cordell, S Tatur, S Wiener, SA Levesque, Scott S. P. Wildman, Toby S. Scott-Ward, V Jankowski, V Kumar, W Yu, Y Cheng, Y Sun, Y Sun, Y Zheng   +60 more
core   +2 more sources

Translocation of neuronal nitric oxide synthase to the plasma membrane by ATP is mediated by P2X and P2Y receptors

Molecular Pain, 2009
Background The translocation of neuronal nitric oxide synthase (nNOS) from the cytosol to the membrane is functionally coupled to the activation of N-methyl-D-aspartate (NMDA) receptors at synapses.
Ohnishi Takayuki, Matsumura Shinji, Ito Seiji   +2 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

Physiological Electrical Signals Promote Chain Migration of Neuroblasts by Up-Regulating P2Y1 Purinergic Receptors and Enhancing Cell Adhesion [PDF]

, 2014
Acknowledgments This work was supported by a grant from NHS Grampian. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
Cao, Lin, Ching, Jared, McCaig, Colin D, Pu, Jin, Scott, Roderick H   +4 more
core   +2 more sources

Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP

BMC Neuroscience, 2007
Background 2-Methylthioadenosine 5'-triphosphate (2-MeSATP), formerly regarded as a specific P2Y (metabotropic) purinergic receptor agonist, stimulates Ca2+ influx and evokes catecholamine release from adrenal chromaffin cells.
Castro Enrique, Tomé Ângelo R, Santos Rosa M, Rosário Luís M   +3 more
doaj   +1 more source

Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks

Purinergic Signalling Purinergic Signalling, 2006
The role of nucleotides in intracellular energy provision and nucleic acid synthesis has been known for a long time. In the past decade, evidence has been presented that, in addition to these functions, nucleotides are also autocrine and paracrine ...
K. Van Kolen, H. Slegers
semanticscholar   +1 more source

Caveolin-1 Regulates P2Y₂ Receptor Signaling during Mechanical Injury in Human 1321N1 Astrocytoma

Biomolecules, 2019
Caveolae-associated protein caveolin-1 (Cav-1) plays key roles in cellular processes such as mechanosensing, receptor coupling to signaling pathways, cell growth, apoptosis, and cancer.
Magdiel Martínez, Namyr A. Martínez, Jorge D. Miranda, Héctor M. Maldonado, Walter I. Silva Ortiz   +4 more
doaj   +1 more source

The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells [PDF]

, 2013
Background: Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release.
Corbalan, J Jose, Jacob, Robert F, Malinski, Tadeusz, Mason, R Preston, Matysiak, Kinga, Szczesny, Damian   +5 more
core   +1 more source