Results 111 to 120 of about 21,917 (273)

Purinergic Signalling and Neurological Diseases: An Update [PDF]

, 2017
Purinergic signalling, i.e. ATP as an extracellular signalling molecule and cotransmitter in both peripheral and central neurons, is involved in the physiology of neurotransmission and neuromodulation.
Burnstock, G
core   +1 more source

Satellite glial cell P2Y₁₂ receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats

Molecular Pain, 2012
Background It has been reported that the P2Y12 receptor (P2Y12R) is involved in satellite glial cells (SGCs) activation, indicating that P2Y12R expressed in SGCs may play functional roles in orofacial neuropathic pain mechanisms. However, the involvement
Katagiri Ayano, Shinoda Masamichi, Honda Kuniya, Toyofuku Akira, Sessle Barry J, Iwata Koichi   +5 more
doaj   +1 more source

Sustained release of prostaglandin E2 in fibroblasts expressing ectopically cyclooxygenase 2 impairs P2Y-dependent Ca2+-mobilization [PDF]

, 1943
The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). P2Y receptors are G protein-coupled receptors expressed in many cell types.
Pimentel-Santillana, María, Través, Paqui G., Pérez-Sen, Raquel, Delicado, Esmerilda G., Martín-Sanz, Paloma, Miras-Portugal, María Teresa, Boscá, Lisardo   +6 more
core   +2 more sources

P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction

Neural Plasticity, 2016
ATP released from neurons and astrocytes during neuronal activity or under pathophysiological circumstances is able to influence information flow in neuronal circuits by activation of ionotropic P2X and metabotropic P2Y receptors and subsequent ...
Segundo J. Guzman, Zoltan Gerevich
doaj   +1 more source

Caveolin-1 Regulates P2Y₂ Receptor Signaling during Mechanical Injury in Human 1321N1 Astrocytoma

Biomolecules, 2019
Caveolae-associated protein caveolin-1 (Cav-1) plays key roles in cellular processes such as mechanosensing, receptor coupling to signaling pathways, cell growth, apoptosis, and cancer.
Magdiel Martínez, Namyr A. Martínez, Jorge D. Miranda, Héctor M. Maldonado, Walter I. Silva Ortiz   +4 more
doaj   +1 more source

The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells [PDF]

, 2013
Background: Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release.
Corbalan, J Jose, Jacob, Robert F, Malinski, Tadeusz, Mason, R Preston, Matysiak, Kinga, Szczesny, Damian   +5 more
core   +1 more source

Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells. [PDF]

J Physiol, 2023
Hool SA, Jeng JY, Jagger DJ, Marcotti W, Ceriani F.   +4 more
europepmc   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Functionalized Congeners of 2H-Chromene P2Y₆ Receptor Antagonists

Cells
The P2Y6 receptor (P2Y6R), a Gq-coupled receptor, is a potential drug discovery target for various inflammatory and degenerative conditions. Antagonists have been shown to attenuate colitis, acute lung injury, etc.
Paola Oliva, Asmita Pramanik, Young-Hwan Jung, Sarah A. Lewicki, Jamie M. Mwendwa, Jong Hwan Park, Kenneth A. Jacobson   +6 more
doaj   +1 more source

Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

BMC Immunology, 2006
Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo, Kong In Deok, Park Kyu Sang, Lee Dong Hyeon, Han Bok Ghee   +4 more
doaj   +1 more source