Results 11 to 20 of about 21,917 (273)
NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. [PDF]
PLoS ONE, 2013 Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell line which expresses all the key enzymes necessary for steroidogenesis. mRNA/protein for multiple P1 (A(2A) and A(2B)), P2X (
Haruhisa Nishi +2 more
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P2Y receptors in neurogenesis [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractG protein‐coupled P2Y receptors (Rs) regulate the function of embryonic and adult neural precursor cells (NPCs) which have the capacity to regenerate and give rise to cells belonging to all three major linages of the nervous system: neurons, oligodendrocytes and astrocytes.
Patrizia Rubini +2 more
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P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. [PDF]
PLoS ONE, 2014 BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking.
Ricardo A Garcia +17 more
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Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice. [PDF]
PLoS ONE, 2012 ATP released in the early inflammatory processes acts as a danger signal by binding to purinergic receptors expressed on immune cells. A major contribution of the P2Y(2) receptor of ATP/UTP to dendritic cell function and Th2 lymphocyte recruitment during
Gilles Vanderstocken +7 more
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P2Y receptors in Alzheimer's disease [PDF]
Biology of the Cell, 2014 Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 10% of people over the age of 65. Age is the greatest risk factor for AD, although a combination of genetic, lifestyle and environmental factors also contribute to disease development.
Laurie Erb +3 more
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Molecules, 2023 The P2Y12 receptor is an important member of the purinergic receptor family, known for its critical role in platelet activation and thrombosis. In our previously published study, the acridinone analogue NSC618159 was identified as a potent antagonist of ...
Belal O. Al-Najjar, Fadi G. Saqallah
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Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractBones are formed and remodeled by the coordinated actions of three key cell types. Osteoblasts, specialized connective tissue cells, deposit and then mineralize the collagenous bone matrix. Osteoclasts, which are derived from promonocytes, resorb mineralized matrix by excavating characteristic pits on bone surfaces.
Timothy R. Arnett, Isabel R. Orriss
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P2Y receptors and kidney function [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractCellular release of nucleotides is of physiological importance to regulate and maintain cell function and integrity. Also in the tubular and collecting duct system of the kidney, nucleotides are released in response to changes in cell volume or luminal flow rate and act in a paracrine and autocrine way on basolateral and luminal P2Y receptors ...
Volker, Vallon +2 more
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Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion. [PDF]
PLoS ONE, 2012 Hyperglycemia is associated with abnormal plasma lipoprotein metabolism and with an elevation in circulating nucleotide levels. We evaluated how extracellular nucleotides may act to perturb hepatic lipoprotein secretion.
Cynthia Chatterjee, Daniel L Sparks
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Pharmaceuticals, 2020 We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y12 receptor and activation of adenosine receptors (AR).
Nina Wolska +4 more
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