Computational and Structural Biotechnology Journal, 2023 Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han +3 more
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P2Y receptors in lung inflammation [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractNucleotides, e.g., adenosine‐5′‐triphosphate (ATP), can be released into the extracellular space under acute or chronic inflammatory conditions and have been shown to serve as potent immunomodulators or danger signals involved in the initiation and maintenance of immune responses.
Tobias Müller, Marco Idzko
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GPR80/99, proposed to be the P2Y15 receptor activated by adenosine and AMP, is not a P2Y receptor [PDF]
Purinergic Signalling Purinergic Signalling, 2004 The orphan receptor GPR80 (also called GPR99) was recently reported to be the P2Y15 receptor activated by AMP and adenosine and coupled to increases in cyclic AMP accumulation and intracellular Ca2+ mobilization (Inbe et al.
Yue Qi +2 more
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P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
Journal of Pharmacological Sciences, 2004 We investigated the effects of P2-receptor agonists on cell size, intracellular calcium levels ([Ca2+]i), and permeation of FITC-labeled dextran (FD-4) as well as the relationship between these effects in human umbilical vein endothelial cells (HUVEC ...
Naoko Tanaka +8 more
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Control of Macrophage Inflammation by P2Y Purinergic Receptors
Cells, 2021 Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity.
Dominik Klaver, Martin Thurnher
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Biochemistry of P2y-purinergic receptors.
Japanese Journal of Pharmacology, 1990 T. Kendall Harden
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Exploration of Fluorinated Pyrazolidine-3,5-Diones for Positron Emission Tomography Imaging of the P2Y<sub>12</sub> Receptor in the Central Nervous System. [PDF]
ChemMedChemStéen EJL +11 more
europepmc +2 more sources
P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. [PDF]
PLoS ONE, 2014 BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking.
Ricardo A Garcia +17 more
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NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. [PDF]
PLoS ONE, 2013 Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell line which expresses all the key enzymes necessary for steroidogenesis. mRNA/protein for multiple P1 (A(2A) and A(2B)), P2X (
Haruhisa Nishi +2 more
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Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice. [PDF]
PLoS ONE, 2012 ATP released in the early inflammatory processes acts as a danger signal by binding to purinergic receptors expressed on immune cells. A major contribution of the P2Y(2) receptor of ATP/UTP to dendritic cell function and Th2 lymphocyte recruitment during
Gilles Vanderstocken +7 more
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