Results 21 to 30 of about 21,917 (273)

ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.

PLoS ONE, 2012
Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Recently, we demonstrated that P2Y(1) and P2Y(12) purinoceptor activities are
Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell   +4 more
doaj   +1 more source

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells

BMC Immunology, 2004
Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders, Jacobsen Sten Eirik W, Wang Lingwei, Erlinge David   +3 more
doaj   +1 more source

Immunolocalisation of P2Y receptors in the rat eye [PDF]

Purinergic Signalling, 2004
Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal wound healing, aqueous humour dynamics and retinal physiology.
Pintor Just, Jesús Jerónimo, Sánchez Nogueiro, Jesús, Irazu, Marta, Mediero Muñoz, Aránzazu, Peláez García, María Teresa, Peral Cerda, María Asunción   +5 more
openaire   +5 more sources

Drug-like antagonists of P2Y receptors — from lead identification to drug development [PDF]

, 2016
P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation.
Conroy, Sean, Kellam, Barrie, Kindon, Nicholas, Stocks, Michael   +3 more
core   +1 more source

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +14 more sources

P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors [PDF]

, 2016
Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders.
Baker, MD, Blackshaw, LA, Boundouki, G, Bulmer, DC, Cibert-Goton, V, Hockley, JRF, Knowles, CH, McGuire, C, Michael, GJ, Thaha, MA, Tranter, MM, Winchester, WJ   +11 more
core   +1 more source

Synthesis, structure-activity relationships and biological evaluation of benzimidazole derived sulfonylurea analogues as a new class of antagonists of P2Y1 receptor

Frontiers in Pharmacology, 2023
The P2Y receptors are responsible for the regulation of various physiological processes including neurotransmission and inflammatory responses. These receptors are also considered as novel potential therapeutic targets for prevention and treatment of ...
Sehrish Bano, Sehrish Bano, Zahid Hussain, Peter Langer, Gary A. Weisman, Jamshed Iqbal, Jamshed Iqbal   +6 more
doaj   +1 more source

P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]

, 2012
P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie, Seye, Cheik I., Weisman, Gary A., Woods, Lucas T.   +3 more
core   +1 more source

Apical membrane P2Y4 purinergic receptor controls K⁺ secretion by strial marginal cell epithelium

Cell Communication and Signaling, 2005
Background It was previously shown that K+ secretion by strial marginal cell epithelium is under the control of G-protein coupled receptors of the P2Y family in the apical membrane.
Scofield Margaret A, Scherer Elias Q, Lee Jun, Liu Jianzhong, Marcus Daniel C, Wangemann Philine   +5 more
doaj   +1 more source

P2Y₆ receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. [PDF]

, 2014
The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and modulates the progression of chronic inflammatory disease through activation of the receptor CCR2.
Antonioli, Ashida, Bachelerie, Boring, Borsellino, Bossink, Campwala, Cathcart, Chen, Cipollone, Communi, Deo, Dinh, Dwyer, Engel, Fung, Gerszten, Griffin, Gu, Hashimoto, Herder, Hiraoka, Hisadome, Huang, Kang, Krause, Lee, Lutgens, Luther, Lévesque, Maus, Mishra, Namiki, North, O'Boyle, Packham, Park, Piemonti, Reutershan, Romanov, Schabath, Serbina, Sivaramakrishnan, Spoettl, Struthers, Suadicani, Tacke, Veillard, von Kügelgen, Wang, Weber, Wei, Weninger, Yu, Zernecke   +54 more
core   +3 more sources