Results 31 to 40 of about 21,917 (273)
Differential inhibitory effects of CysLT(1) receptor antagonists on P2Y(6) receptor-mediated signaling and ion transport in human bronchial epithelia. [PDF]
PLoS ONE, 2011 BACKGROUND: Cysteinyl leukotriene (CysLT) is one of the proinflammatory mediators released by the bronchi during inflammation. CysLTs exert their biological effects via specific G-protein-coupled receptors. CysLT(1) receptor antagonists are available for
Wendy Ka-hoi Lau +3 more
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ATP as a presynaptic modulator [PDF]
, 2000 © 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core +1 more source
Purinergic receptor mediated calcium signalling in urothelial cells [PDF]
, 2019 Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the potential for ...
Brierley, Stuart M +4 more
core +3 more sources
Journal of Cardiovascular Development and Disease, 2023 Dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and an inhibitor of the platelet P2Y12 receptor for ADP, remains among the most investigated treatments in cardiovascular medicine.
Giulia Alagna +3 more
doaj +1 more source
P2Y Receptors in Bone - Anabolic, Catabolic, or Both? [PDF]
Frontiers in Endocrinology, 2022 P2Y receptors, including eight subtypes, are G protein-coupled receptors that can be activated by extracellular nucleotides. Nearly all P2Y receptors are expressed in bone cells, suggesting their involvements in bone physiology and pathology. However, their exact roles in bone homeostasis are not entirely clear.
Zhou, Y., Arredondo, H.M., Wang, N.
openaire +3 more sources
P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King +29 more
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P2Y receptors in the gastrointestinal epithelium [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractP2Y receptors are widely expressed in all gastrointestinal (GI) epithelia. Commonly, one epithelial tissue or cell expresses several P2Y receptors, which are located in both the apical and basolateral membranes. In almost all studied GI tissues, stimulation of P2Y receptors activates ion secretion, either that of NaCl, KCl, NaHCO3, or KHCO3. In
Larsen, Casper Kornbech +1 more
openaire +3 more sources
Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
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Biomolecules, 2021 Nucleotides released by smooth muscle cells (SMCs) and by innervating nerve terminals activate specific P2 receptors and modulate bladder contraction. We hypothesized that cell surface enzymes regulate SMC contraction in mice bladder by controlling the ...
Romuald Brice Babou Kammoe +4 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
core +3 more sources