Results 41 to 50 of about 2,327,568 (312)

P2Y receptors and pain transmission [PDF]

Purinergic Signalling, 2004
It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X(3) and P2X(2/3) subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y(1) and P2Y(2) receptors are
Gerevich, Zoltan, Illes, Peter
openaire   +2 more sources

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E, Craigie, Eilidh, Unwin, Robert J, Wildman, Scott S.P.   +3 more
core   +3 more sources

Purinergic effects on Na,K-ATPase activity differ in rat and human skeletal muscle. [PDF]

PLoS ONE, 2014
P2Y receptor activation may link the effect of purines to increased maximal in vitro activity of the Na,K-ATPase in rat muscle. The hypothesis that a similar mechanism is present in human skeletal muscle was investigated with membranes from rat and human
Carsten Juel, Nikolai B Nordsborg, Jens Bangsbo   +2 more
doaj   +1 more source

Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase*

Journal of Biological Chemistry, 1997
Clones encoding a new human P2Y receptor, provisionally called P2Y11, have been isolated from human placenta complementary DNA and genomic DNA libraries. The 1113-base pair open reading frame is interrupted by one intron.
D. Communi, C. Govaerts, M. Parmentier, J. Boeynaems   +3 more
semanticscholar   +1 more source

P2X1 receptors and the endothelium

Memorias do Instituto Oswaldo Cruz, 2005
Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families.
LS Harrington, JA Mitchell
doaj   +1 more source

P2Y₆ receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. [PDF]

, 2014
The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and modulates the progression of chronic inflammatory disease through activation of the receptor CCR2.
Antonioli, Ashida, Bachelerie, Boring, Borsellino, Bossink, Campwala, Cathcart, Chen, Cipollone, Communi, Deo, Dinh, Dwyer, Engel, Fung, Gerszten, Griffin, Gu, Hashimoto, Herder, Hiraoka, Hisadome, Huang, Kang, Krause, Lee, Lutgens, Luther, Lévesque, Maus, Mishra, Namiki, North, O'Boyle, Packham, Park, Piemonti, Reutershan, Romanov, Schabath, Serbina, Sivaramakrishnan, Spoettl, Struthers, Suadicani, Tacke, Veillard, von Kügelgen, Wang, Weber, Wei, Weninger, Yu, Zernecke   +54 more
core   +3 more sources

A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

eLife, 2019
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown.
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo   +14 more
doaj   +1 more source

Effects of 4(1H)-quinolinone derivative, a novel non-nucleotide allosteric purinergic P2Y 2 agonist, on cardiomyocytes in neonatal rats

Scientific Reports, 2017
Purinergic P2Y 2 receptors, G-protein coupled receptors that primarily couple with Gαq/11-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate.
Kensuke Sakuma, Hideyuki Nakagawa, Tatsuo Oikawa, Masakuni Noda, Shota Ikeda   +4 more
doaj   +1 more source

ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source

Identification of High Platelet Reactivity Despite ADP P2Y12 Inhibitor Treatment: Two Populations in the Vasodilator-Stimulated Phosphoprotein Assay and Variable PFA-P2Y Shapes of Curve

TH Open, 2023
Introduction Response to ADP P2Y12 receptor inhibition by clopidogrel can be evaluated by various techniques. Here, we compared a functional rapid point-of-care technique (PFA-P2Y) with the degree of biochemical inhibition assessed by the VASP/P2Y12 ...
Cyril Mariethoz, Emmanuelle Scala, Elena Matthey-Guirao, Jean-Benoît Rossel, Francisco Javier Gomez, Francesco Grandoni, Carlo Marcucci, Lorenzo Alberio   +7 more
doaj   +1 more source