Results 41 to 50 of about 21,917 (273)

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Computational and Structural Biotechnology Journal, 2023
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han, Hongryul Yoon, Jiho Yoo, Yoonji Lee   +3 more
doaj  

P2X1 receptors and the endothelium

Memorias do Instituto Oswaldo Cruz, 2005
Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families.
LS Harrington, JA Mitchell
doaj   +1 more source

Purinergic effects on Na,K-ATPase activity differ in rat and human skeletal muscle. [PDF]

PLoS ONE, 2014
P2Y receptor activation may link the effect of purines to increased maximal in vitro activity of the Na,K-ATPase in rat muscle. The hypothesis that a similar mechanism is present in human skeletal muscle was investigated with membranes from rat and human
Carsten Juel, Nikolai B Nordsborg, Jens Bangsbo   +2 more
doaj   +1 more source

P2Y receptors in lung inflammation [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractNucleotides, e.g., adenosine‐5′‐triphosphate (ATP), can be released into the extracellular space under acute or chronic inflammatory conditions and have been shown to serve as potent immunomodulators or danger signals involved in the initiation and maintenance of immune responses.
Tobias Müller, Marco Idzko
openaire   +2 more sources

Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]

, 2017
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R, Gueneri, D, Hajjawai, M O, Orriss, I R, Patel, J J, Shaw, K   +5 more
core   +2 more sources

Effects of 4(1H)-quinolinone derivative, a novel non-nucleotide allosteric purinergic P2Y 2 agonist, on cardiomyocytes in neonatal rats

Scientific Reports, 2017
Purinergic P2Y 2 receptors, G-protein coupled receptors that primarily couple with Gαq/11-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate.
Kensuke Sakuma, Hideyuki Nakagawa, Tatsuo Oikawa, Masakuni Noda, Shota Ikeda   +4 more
doaj   +1 more source

A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

eLife, 2019
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown.
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo   +14 more
doaj   +1 more source

Anti-platelet therapy: ADP receptor antagonists. [PDF]

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD
core   +2 more sources

Identification of High Platelet Reactivity Despite ADP P2Y12 Inhibitor Treatment: Two Populations in the Vasodilator-Stimulated Phosphoprotein Assay and Variable PFA-P2Y Shapes of Curve

TH Open, 2023
Introduction Response to ADP P2Y12 receptor inhibition by clopidogrel can be evaluated by various techniques. Here, we compared a functional rapid point-of-care technique (PFA-P2Y) with the degree of biochemical inhibition assessed by the VASP/P2Y12 ...
Cyril Mariethoz, Emmanuelle Scala, Elena Matthey-Guirao, Jean-Benoît Rossel, Francisco Javier Gomez, Francesco Grandoni, Carlo Marcucci, Lorenzo Alberio   +7 more
doaj   +1 more source

Functional distribution of Ca²⁺-coupled P2 purinergic receptors among adrenergic and noradrenergic bovine adrenal chromaffin cells

BMC Neuroscience, 2007
Background Adrenal chromaffin cells mediate acute responses to stress through the release of epinephrine. Chromaffin cell function is regulated by several receptors, present both in adrenergic (AD) and noradrenergic (NA) cells.
Castro Enrique, Tomé Ângelo R, Santos Rosa M, Rosário Luís M   +3 more
doaj   +1 more source