Results 61 to 70 of about 21,917 (273)

GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors

BMC Bioinformatics, 2008
Background GPR17 is a G-protein-coupled receptor located at intermediate phylogenetic position between two distinct receptor families: the P2Y and CysLT receptors for extracellular nucleotides and cysteinyl-LTs, respectively.
Ranghino Graziella, Abbracchio Maria P, Parravicini Chiara, Fantucci Piercarlo   +3 more
doaj   +1 more source

Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids

Bioengineering, 2022
Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpenoids
Liliya E. Nikitina, Roman S. Pavelyev, Ilmir R. Gilfanov, Sergei V. Kiselev, Zulfiya R. Azizova, Alexander A. Ksenofontov, Pavel S. Bocharov, Elena V. Antina, Vladimir V. Klochkov, Ayzira F. Timerova, Ilfat Z. Rakhmatullin, Olga V. Ostolopovskaya, Mohammed A. Khelkhal, Sergei V. Boichuk, Aigul R. Galembikova, Natalia S. Andriutsa, Larisa L. Frolova, Alexander V. Kutchin, Airat R. Kayumov   +18 more
doaj   +1 more source

Effect of P2Y12 Inhibitors on Major Adverse Cardiovascular Events After Coronary Artery Bypass Graft Surgery: A Population‐Based Cohort Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background Patients who undergo coronary artery bypass graft (CABG) surgery remain at high risk for major adverse cardiovascular events (MACE) despite contemporary preventive pharmacotherapy. Although commonly used in practice, it is uncertain whether P2Y12 inhibitors reduce MACE in patients post‐CABG surgery.
Arden R. Barry, Hamed Helisaz, Abdollah Safari, Peter S. Loewen   +3 more
wiley   +1 more source

Physiological Electrical Signals Promote Chain Migration of Neuroblasts by Up-Regulating P2Y1 Purinergic Receptors and Enhancing Cell Adhesion [PDF]

, 2014
Acknowledgments This work was supported by a grant from NHS Grampian. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
Cao, Lin, Ching, Jared, McCaig, Colin D, Pu, Jin, Scott, Roderick H   +4 more
core   +2 more sources

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, EarlyView.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

P2Y receptors in GtoPdb v.2021.3

IUPHAR/BPS Guide to Pharmacology CITE, 2021
P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5, 192]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use ...
Gary A. Weisman, Vera Ralevic, Maria Teresa Miras-Portugal, Christa E. Müller, Davide Lecca, Brian F. King, Charles Kennedy, Kenneth A. Jacobson, Kazu Inoue, Robert G. Humphries, Rebecca Hills, Christian Gachet, Marta Fumagalli, Stefania Ceruti, Geoffrey Burnstock, José L. Boyer, Jean-Marie Boeynaems, Maria-Pia Abbracchio   +17 more
openaire   +3 more sources

Immunogold electron microscopic evidence of in situ formation of homo- and heteromeric purinergic adenosine A₁ and P2Y₂ receptors in rat brain

BMC Research Notes, 2010
Background Purines such as adenosine and ATP are now generally recognized as the regulators of many physiological functions, such as neurotransmission, pain, cardiac function, and immune responses.
Suzuki Tokiko, Namba Kazunori, Nakata Hiroyasu   +2 more
doaj   +1 more source

In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors

Biomolecules, 2020
Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj   +1 more source

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes

Molecules, 2022
Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato, Francesca Favaretto, Marnie Granzotto, Marika Crescenzi, Alessandra Boscaro, Angelo Di Vincenzo, Federico Capone, Edoardo Dalla Nora, Eva Zabeo, Roberto Vettor   +9 more
doaj   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source