Results 41 to 50 of about 14,908 (109)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

3D Liver Fibrosis Models in Lab: A Novel Modality for Drug Screening

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Liver fibrosis is the common consequence of liver injury caused by a variety of chronic liver disorders. This condition leads to the development of more severe complications, particularly cirrhosis and hepatocellular carcinoma. Despite abundant studies, the fundamental cell and molecular mechanisms of liver fibrosis are still unknown.
Hani Keshavarz Alikhani, Fatemeh Majidi, Mahsa Ghasemzad, Anastasia Shpichka, Anastasia Nestorova, Zahra Hendi, Elham Rismani, Daria Kuznetsova, Peter Timashev, Massoud Vosough, Abbas Piryaei   +10 more
wiley   +1 more source

Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson‐Gilford Progeria Syndrome Cells, Preventing Its Own Autophagic Degradation

Aging Cell, Volume 25, Issue 8, August 2026.
We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre, Jesús Alejandro Reyes‐Martínez, Juan Unzueta, Francisco Guevara‐Namorado, Solangy Lizcano‐Meneses, Susana Gonzalo, Angel Baldan, Claudia Rangel, Gerardo J. Alanis‐Funes, Francisco Garcia‐Sierra, Kevin Ruiz‐Fajardo, Simon Gormes‐Pinchanski, Susana Castro‐Obregón, Aranza Meza‐Dorantes, Rocio Alejandra Chavez‐Santoscoy, Isabel Arrieta‐Cruz, Paola Tristán‐Aburto, Jonathan J. Magaña, Bulmaro Cisneros   +18 more
wiley   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1268-1282, August 2026.
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
wiley   +1 more source

FREQ‐NESS Reveals Age‐Related Differences in Frequency‐Resolved Brain Networks During Auditory Recognition and Resting State

Annals of the New York Academy of Sciences, Volume 1562, Issue 1, August 2026.
We adapted the FREQ‐NESS pipeline to event‐related MEG data from 140 adults during a melody‐recognition task, revealing an age‐related reorganization of frequency‐specific brain networks. Younger adults showed task‐related reduction in the prominence of alpha networks, whereas older adults maintained prominent slower alpha networks (8.6–10.0 Hz) across
Chiara Malvaso, Gemma Fernández‐Rubio, Mattia Rosso, Elisa Serra, Vera Rudi, Peter Vuust, Morten L. Kringelbach, Claudia Testa, Leonardo Bonetti   +8 more
wiley   +1 more source

DcH3.3 and DcNAC1 Regulate the Expression of UGT73A93 Involved in the Changes in Flower Colour and Fungal Resistance in Carnation

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4863-4877, August 2026.
ABSTRACT Carnation (Dianthus caryophyllus) contains abundant flavonoid glycosides (FGs), which are important natural functional and colour components. However, there are few reports on the modification of UDP‐glycosyltransferases (UGTs) in relation to flavonoids in carnation.
Xuhong Zhou, Qirui Xiong, Yue Zhang, Xiumei Yang, Siyuan Zhang, Yanxia Tao, Xiaomi Yang   +6 more
wiley   +1 more source

A Myocyte‐Enriched Long Non‐Coding RNA NRMLncR Enhances Myogenesis in Mouse

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
We identified a novel myocyte‐enriched, Notch‐repressed myogenic lncRNA, NRMLncR, that is induced by myogenic regulatory factors (MRFs) during myogenic progression in mouse. NRMLncR localizes to cytoplasmic and nuclear compartments, associates with the RNA‐binding protein CUGBP Elav‐like family member 1 (CELF1), and is linked to neighboring gene Tbx1 ...
Yufen Li, Yumei Zhou, Qing Ying Li, Justine Arrington, Zhengzheng Hu, Mostafa F. Abdelhai, Yubo Wang, Junxiao Ren, Yung‐Yu Cheng, Mingyi Xie, W. Andy Tao, Shihuan Kuang, Feng Yue   +12 more
wiley   +1 more source

Enhancing Oncolytic Adenovirus Replication by Early Region 1A Protein-Mediated Degradation of E1A Binding Protein p300. [PDF]

MedComm (2020)
Xiao B, Yang Q, Hu S, Hu J, Qi Z, Zhang Y, Qin Y, Cheng P.   +7 more
europepmc   +1 more source