Zhongguo shiyan zhenduanxue目的 探究肝硬化合并腹水患者的发病危险因素，为肝硬化合并腹水的防治提供依据。方法 选取健康人68名(健康对照组)、肝硬化代偿期患者70例(肝硬化代偿组)和肝硬化失代偿期患者70例(肝硬化失代偿组)。采用酶联免疫吸附测定法(ELISA)试剂盒检测各组研究对象肝功能指标，采用流式血细胞分析仪检测各组研究对象白细胞计数(WBC)、中性粒细胞计数(NE)、血小板计数(PLT),采用16S rDNA分析各组研究对象肠道菌群情况，采用ELISA试剂盒测定各组研究对象炎症因子及内毒素水平 ...
赵洋 +4 more
doaj
髓核源性坐骨神经痛大鼠背根神经节磷酸化 p38MAPK表达的变化
Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 观察髓核源性坐骨神经痛大鼠模型中背根神经节磷酸化p38丝裂原活化蛋白激酶(p-p38MAPK)表达的变化及其与炎性反应和机械痛敏的关系,以探讨腰椎间盘突出症的病理机制65377; 【方法】 选择成年SD雄性大鼠66只随机分为空白组(12只)65380;假手术组(18只)和模型组(36只)65377;模型组在左腰5神经背根神经节(L5DRG)自体髓核移植以建立大鼠非压迫性腰椎间盘突出模型,假手术组自体肌肉移植65377;空白组不进行手术65377;测量各组大鼠术前至术后21 d的左后肢50 ...
doaj
ＳＢ２０２１９０对卡英酸诱导的癫痫大鼠模型认知功能的影响及机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要：【目的】 研究ｐ３８丝裂原活化蛋白激酶（ｐ３８ＭＡＰＫ）选择性抑制剂ＳＢ２０２１９０对卡英酸（ＫＡ）致痫大鼠学习、记忆能力的影响及其与海马神经元凋亡的关系的探讨。【方法】４０只大鼠随机分为４组：假处理组、模型组和ＳＢ２０２１９０低、高剂量组（剂量分别为７．５ ｍｇ／ｋｇ，３０ ｍｇ／ｋｇ），对各组大鼠进行行为学观察，应用Ｍｏｒｒｉｓ水迷宫试验，检测大鼠学习和记忆能力，同时通过ＢＬ－４２０Ｆ生物机能实验系统描记脑电图的变化，采用 ＴＵＮＥＬ 检测细胞凋亡并计算凋亡率 ...
doaj
miRNA-124调控ERK/p38 MAPK-NLRP3通路对脓毒症心肌损伤的作用机制
Zhongguo shiyan zhenduanxue目的探讨miRNA-124通过调控ERK/p38 MAPK-NLRP3炎性小体通路对脓毒症心肌损伤的作用。方法选取50只C57BL/6小鼠，随机分为正常对照组、模型组、miRNA-124敲除模型组、ERK抑制剂组和p38MAPK抑制剂组5组，每组10只。采用H&E染色评估心脏损伤，TUNEL法检测凋亡，ELISA测定炎症因子水平，Western blot分析相关蛋白表达。结果模型组出现明显的心肌细胞浸润、水肿和坏死，伴随凋亡增加及TNF-α、IL-1β、IL-6等炎症因子升高，miRNA ...
吴言悟 +5 more
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[Interferon-λ1 improves glucocorticoid resistance caused by respiratory syncytial virus by regulating the p38 mitogen-activated protein kinase signaling pathway]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiPeng L +6 more
europepmc +1 more source
[Effect of ginsenoside Rb3 on experimental periodontitis in rats]. [PDF]
Hua Xi Kou Qiang Yi Xue Za ZhiLi H, Zhang K, Qu H, Ji H, Sun M.
europepmc +1 more source
[Research progress on lactylation modification in pathogenesis of osteoarthritis]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiWu Y +7 more
europepmc +1 more source
[Pathogenesis and mechanism of serine protease 23 in skin fibrosis of systemic sclerosis]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanYuan X, Li Z, Xu D, Li T, Fang D, Mu R.
europepmc +1 more source
[Biological activities of <i>Polygonatum</i> polysaccharides and their roles in the prevention and treatment of related diseases]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanGuan P +5 more
europepmc +1 more source
[<i>Shenqi Xiezhuo</i> Decoction alleviates renal fibrosis in rats by ameliorating oxidative stress and inflammation through the Rap1/MAPK/FoxO3a signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLu X +6 more
europepmc +1 more source