Results 11 to 20 of about 104,805 (160)
Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation. [PDF]
Adv Sci (Weinh)TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Deng Z +12 more
europepmc +2 more sources
Recent progress in thermosensitive hydrogels and their applications in drug delivery area
MedComm – Biomaterials and Applications, Volume 2, Issue 3, September 2023., 2023 Review Paper highlighted the background of thermosensitive hydrogels, their properties, and their applications in transdermal, oral, ophthalmic, intravaginal, nasal, rectal, cancer therapy, and cell‐loaded drug delivery systems as shown in the preview.
Bangul Khan +10 more
wiley +1 more source
International Journal of Language &Communication Disorders, Volume 58, Issue 4, Page 1113-1132, July/August 2023., 2023 Abstract Background A number of practice barriers (e.g., time constraints, patient comorbidities and competing demands) exist as regards the evidence‐based assessment of adult language within the acute hospital setting. There is need for an evidence‐based, diagnostically validated, adaptable, comprehensive and efficient aphasia assessment. The Brisbane
Rhiannon Hounslow +2 more
wiley +1 more source
RAS‐targeted cancer therapy: Advances in drugging specific mutations
MedComm, Volume 4, Issue 3, June 2023., 2023 Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu +7 more
wiley +1 more source
Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023 Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 179, Issue 24, Page 5273-5289, December 2022., 2022 Background and Purpose Donepezil, a piperidine inhibitor of acetylcholinesterase (AChE) prescribed for treatment of Alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non‐depolarising neuromuscular blockers during surgery.
Robert R. Redman +4 more
wiley +1 more source
Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
ChemMedChem, Volume 17, Issue 18, September 16, 2022., 2022 Substrate mimicry: Substrate peptidomimetics were designed and showed potent inhibition of plasmepsin X (PMX). The peptidomimetics block PMX ligand processing, arrest asexual parasites at the schizont stage and potently kill P. falciparum parasites. The peptidomimetics will further assist in the understanding of PMX selectivity and in the development ...
Lachlan W. Richardson +10 more
wiley +1 more source
Piezoelectric Polymeric Foams as Flexible Energy Harvesters: A Review
Advanced Energy and Sustainability Research, Volume 3, Issue 9, September 2022., 2022 Advances in conventional and recent polymeric foam‐based piezoelectrics considering their various generation technology and various polymer systems are summarized for energy‐harvesting applications. Piezoelectric energy harvesters (PEHs) have the potential to power low‐power electronic devices and can advance, self‐powered, autonomous electronics to ...
Manauwar Ali Ansari, Patcharapon Somdee
wiley +1 more source
PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6
Annals of the New York Academy of Sciences, Volume 1515, Issue 1, Page 196-207, September 2022., 2022 We evaluated the role of class I PI3Kγ in the setting of TNFα‐mediated barrier breakdown in human HT‐29/B6 colon carcinoma cells by comparing wild‐type and PI3Kγ catalytic subunit–deficient cells. We provide evidence that loss of PI3Kγ in HT‐29/B6 cells affects basal regulation of claudin‐2, and that the scaffolding function of PI3Kγ mediates the ...
Franz‐Leonard Klaus +4 more
wiley +1 more source
Kwartalnik Filmowy, 2015 Artykuł sytuuje Ostatni etap pośród tych filmowych świadectw i reprezentacji, których rewizjonistyczna reinterpretacja daje poznawcze rezultaty w dziedzinie gender studies.
Monika Talarczyk-Gubała
doaj +1 more source