Results 11 to 20 of about 91,138 (160)
British Journal of Pharmacology, Volume 179, Issue 24, Page 5273-5289, December 2022., 2022 Background and Purpose Donepezil, a piperidine inhibitor of acetylcholinesterase (AChE) prescribed for treatment of Alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non‐depolarising neuromuscular blockers during surgery.
Robert R. Redman +4 more
wiley +1 more source
Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
ChemMedChem, Volume 17, Issue 18, September 16, 2022., 2022 Substrate mimicry: Substrate peptidomimetics were designed and showed potent inhibition of plasmepsin X (PMX). The peptidomimetics block PMX ligand processing, arrest asexual parasites at the schizont stage and potently kill P. falciparum parasites. The peptidomimetics will further assist in the understanding of PMX selectivity and in the development ...
Lachlan W. Richardson +10 more
wiley +1 more source
Piezoelectric Polymeric Foams as Flexible Energy Harvesters: A Review
Advanced Energy and Sustainability Research, Volume 3, Issue 9, September 2022., 2022 Advances in conventional and recent polymeric foam‐based piezoelectrics considering their various generation technology and various polymer systems are summarized for energy‐harvesting applications. Piezoelectric energy harvesters (PEHs) have the potential to power low‐power electronic devices and can advance, self‐powered, autonomous electronics to ...
Manauwar Ali Ansari, Patcharapon Somdee
wiley +1 more source
PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6
Annals of the New York Academy of Sciences, Volume 1515, Issue 1, Page 196-207, September 2022., 2022 We evaluated the role of class I PI3Kγ in the setting of TNFα‐mediated barrier breakdown in human HT‐29/B6 colon carcinoma cells by comparing wild‐type and PI3Kγ catalytic subunit–deficient cells. We provide evidence that loss of PI3Kγ in HT‐29/B6 cells affects basal regulation of claudin‐2, and that the scaffolding function of PI3Kγ mediates the ...
Franz‐Leonard Klaus +4 more
wiley +1 more source
Clinical profiles of subsequent stages in bipolar disorder: Results from the Dutch Bipolar Cohort
Bipolar Disorders, Volume 24, Issue 4, Page 424-433, June 2022., 2022 Abstract Introduction The manifestation of bipolar disorder (BD) is hypothesized to be determined by clinical characteristics such as familial loading, childhood abuse, age at onset, illness duration, comorbid psychiatric disorders, addiction, treatment resistance, and premorbid cognitive functioning.
Afra van der Markt +6 more
wiley +1 more source
Aquaculture Environment Interactions, 2019 The rapid development of the aquaculture industry has led to the growth of environmental problems. Bioremediation is an effective method for treating aquaculture effluents.
Zhao, L +6 more
doaj +1 more source
Image Analysis and Stereology, 2011 Water diffusion tensor magnetic resonance imaging (DT-MRI) is a non-invasive and sensitive modality that is becoming increasingly popular in diagnostic radiology. DT-MRI provides in vivo directional information about the organization and microdynamics of
Khader M Hasan +2 more
doaj +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Background. Li Chang decoction (LCD), a Chinese medicine formula, is commonly used to treat ulcerative colitis (UC) in clinics. Purpose. This study aimed to identify the major components in LCD and its prototype and metabolic components in rat biological samples. Methods. The chemical constituents in LCD were identified by establishing a reliable ultra‐
Baofu Lin +11 more
wiley +1 more source
Unveiling Radical Mediation: Navigating Body-Mind, Affect, and Technology in Media Literacy [PDF]
, 2023 Combating disinformation fake news and hate speech has become one of the main challenges for media literacy studies Recent research reveals that affective emotional factors and confirmation bias prevail in how users interact with media content This ...
Fátima Regis de Oliveira
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Background. Shenlingbaizhu powder (SLBZP), one of the classic Earth‐cultivating and gold‐generating prescriptions of traditional Chinese medicine, is widely used to treat various diseases. However, the pharmacological mechanisms of SLBZP on bronchial asthma (BA) and allergic colitis (AC) remain to be elucidated. Methods.
Liying Zeng +8 more
wiley +1 more source