Results 11 to 20 of about 39,153,651 (173)

Improvement of the Antibacterial Activity of Phage Lysin-Derived Peptide P87 through Maximization of Physicochemical Properties and Assessment of Its Therapeutic Potential. [PDF]

Antibiotics (Basel), 2022
Phage lysins are a promising alternative to common antibiotic chemotherapy. However, they have been regarded as less effective against Gram-negative pathogens unless engineered, e.g., by fusing them to antimicrobial peptides (AMPs).
Vázquez R, Doménech-Sánchez A, Ruiz S, Sempere J, Yuste J, Albertí S, García P.   +6 more
europepmc   +2 more sources

Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation. [PDF]

Adv Sci (Weinh)
TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Deng Z, Chen J, Yang R, Zhan Y, Chen S, Zhang J, Fu H, Gu Y, Huang Q, Wu J, Shan L, Gounni AS, Xie J.   +12 more
europepmc   +2 more sources

OpMNPV p87, a baculovirus capsid protein : genetic location, nucleotide sequence, transcriptional mapping and immunochemical characterization [PDF]

A capsid protein termed p87 of the Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus (OpMNPV) was located to the HindIII-G fragment of the viral genome by Southern hybridization. A 3.6 kb segment of this region was sequenced and an 1872-nt open
Müller, Rolf
core   +6 more sources

Bacteriophages as a Strategy to Protect Potato Tubers against Dickeya dianthicola and Pectobacterium carotovorum Soft Rot. [PDF]

Microorganisms, 2022
The protective effect of bacteriophage suspensions (Ds3CZ + Ds20CZ and PcCB7V + PcCB251) on phytopathogenic bacteria causing soft rot of potato tubers, namely Dickeya dianthicola (D50, D200) and Pectobacterium carotovorum (P87, P224), was observed in ex ...
Beňo F, Horsáková I, Kmoch M, Petrzik K, Krátká G, Ševčík R.   +5 more
europepmc   +2 more sources

Insights into Api m 10-Isoforms and Splice Variants: More Than One Major IgE-Binding Epitope. [PDF]

Clin Transl Allergy
The structural, clinical and preclinical insights into Api m 10 and its immunodominant epitopes gained in this study provide substantial insights for the future development of active and passive VIT as well as further treatment approaches. ABSTRACT Background Honey bee venom (HBV) often triggers severe IgE‐mediated allergies.
Paulus-Tremel KE, Wolff MB, Novak N, Wagner N, Landgraf A, Schülke S, Holzhauser T, Mahler V.   +7 more
europepmc   +2 more sources

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

MedComm – Biomaterials and Applications, Volume 2, Issue 3, September 2023., 2023
Review Paper highlighted the background of thermosensitive hydrogels, their properties, and their applications in transdermal, oral, ophthalmic, intravaginal, nasal, rectal, cancer therapy, and cell‐loaded drug delivery systems as shown in the preview.
Bangul Khan, Areesha Arbab, Samiullah Khan, Hajira Fatima, Isha Bibi, Narinder P. Chowdhry, Abdul Q. Ansari, Ahsan A. Ursani, Sanjay Kumar, Jawad Hussain, Saad Abdullah   +10 more
wiley   +1 more source

What is the usage of the Brisbane Evidence Based Language Test in clinical practice?: A speech language therapy survey

International Journal of Language &Communication Disorders, Volume 58, Issue 4, Page 1113-1132, July/August 2023., 2023
Abstract Background A number of practice barriers (e.g., time constraints, patient comorbidities and competing demands) exist as regards the evidence‐based assessment of adult language within the acute hospital setting. There is need for an evidence‐based, diagnostically validated, adaptable, comprehensive and efficient aphasia assessment. The Brisbane
Rhiannon Hounslow, Alexia Rohde, Emma Finch   +2 more
wiley   +1 more source

RAS‐targeted cancer therapy: Advances in drugging specific mutations

MedComm, Volume 4, Issue 3, June 2023., 2023
Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu, Danyang Ye, Hongliu Yang, Xu Chen, Zhijun Su, Xia Li, Mei Ding, Yonggang Liu   +7 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

Imaging of TDH3-WOR3 biofilms in the P87 and P75010 backgrounds.

, 2023
Biofilms were imaged after 24 hrs at 37°C in RPMI+10% FBS for WT, efg1Δ/Δ, and efg1Δ/Δ TDH3-WOR3 strains derived from P87 (Panel A) or P75010 (Panel B) using the “Silicone substrate–confocal microscopy” method. Maximum intensity apical projections of the
Max V. Cravener (14504895), Eunsoo Do (6869054), Aaron P. Mitchell (8339220), Robert Zarnowski (146240), C. Joel McManus (4252246), Gemma May (6446756), David R. Andes (146260)   +6 more
core   +1 more source