Results 11 to 20 of about 103,216 (162)

Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation. [PDF]

Adv Sci (Weinh)
TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Deng Z, Chen J, Yang R, Zhan Y, Chen S, Zhang J, Fu H, Gu Y, Huang Q, Wu J, Shan L, Gounni AS, Xie J.   +12 more
europepmc   +2 more sources

Insights into Api m 10‐Isoforms and Splice Variants: More Than One Major IgE‐Binding Epitope [PDF]

Clin Transl Allergy
The structural, clinical and preclinical insights into Api m 10 and its immunodominant epitopes gained in this study provide substantial insights for the future development of active and passive VIT as well as further treatment approaches. ABSTRACT Background Honey bee venom (HBV) often triggers severe IgE‐mediated allergies.
Paulus‐Tremel K, Wolff M, Novak N, Wagner N, Landgraf A, Schülke S, Holzhauser T, Mahler V.   +7 more
europepmc   +2 more sources

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

MedComm – Biomaterials and Applications, Volume 2, Issue 3, September 2023., 2023
Review Paper highlighted the background of thermosensitive hydrogels, their properties, and their applications in transdermal, oral, ophthalmic, intravaginal, nasal, rectal, cancer therapy, and cell‐loaded drug delivery systems as shown in the preview.
Bangul Khan, Areesha Arbab, Samiullah Khan, Hajira Fatima, Isha Bibi, Narinder P. Chowdhry, Abdul Q. Ansari, Ahsan A. Ursani, Sanjay Kumar, Jawad Hussain, Saad Abdullah   +10 more
wiley   +1 more source

What is the usage of the Brisbane Evidence Based Language Test in clinical practice?: A speech language therapy survey

International Journal of Language &Communication Disorders, Volume 58, Issue 4, Page 1113-1132, July/August 2023., 2023
Abstract Background A number of practice barriers (e.g., time constraints, patient comorbidities and competing demands) exist as regards the evidence‐based assessment of adult language within the acute hospital setting. There is need for an evidence‐based, diagnostically validated, adaptable, comprehensive and efficient aphasia assessment. The Brisbane
Rhiannon Hounslow, Alexia Rohde, Emma Finch   +2 more
wiley   +1 more source

RAS‐targeted cancer therapy: Advances in drugging specific mutations

MedComm, Volume 4, Issue 3, June 2023., 2023
Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu, Danyang Ye, Hongliu Yang, Xu Chen, Zhijun Su, Xia Li, Mei Ding, Yonggang Liu   +7 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle

British Journal of Pharmacology, Volume 179, Issue 24, Page 5273-5289, December 2022., 2022
Background and Purpose Donepezil, a piperidine inhibitor of acetylcholinesterase (AChE) prescribed for treatment of Alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non‐depolarising neuromuscular blockers during surgery.
Robert R. Redman, Harry Mackenzie, Kosala N. Dissanayake, Michael Eddleston, Richard R. Ribchester   +4 more
wiley   +1 more source

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity

ChemMedChem, Volume 17, Issue 18, September 16, 2022., 2022
Substrate mimicry: Substrate peptidomimetics were designed and showed potent inhibition of plasmepsin X (PMX). The peptidomimetics block PMX ligand processing, arrest asexual parasites at the schizont stage and potently kill P. falciparum parasites. The peptidomimetics will further assist in the understanding of PMX selectivity and in the development ...
Lachlan W. Richardson, Trent D. Ashton, Madeline G. Dans, Nghi Nguyen, Paola Favuzza, Tony Triglia, Anthony N. Hodder, Anna Ngo, Kate E. Jarman, Alan F. Cowman, Brad E. Sleebs   +10 more
wiley   +1 more source

Piezoelectric Polymeric Foams as Flexible Energy Harvesters: A Review

Advanced Energy and Sustainability Research, Volume 3, Issue 9, September 2022., 2022
Advances in conventional and recent polymeric foam‐based piezoelectrics considering their various generation technology and various polymer systems are summarized for energy‐harvesting applications. Piezoelectric energy harvesters (PEHs) have the potential to power low‐power electronic devices and can advance, self‐powered, autonomous electronics to ...
Manauwar Ali Ansari, Patcharapon Somdee
wiley   +1 more source

PENGELOLAAN DANA KEMAHASISWAAN: KECURANGAN DAN MODUS MELAKUKANNYA [PDF]

, 2022
ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan modus kecurangan dalam pengelolaan dana kemahasiswaan yang berpotensi menghambat terwujudnya akuntabilitas dalam Good University Governance (GUG).
Damayanti, Rhosalina, Hapsari, Aprina Nugrahesthy Sulistya, Rompis, Adrian Izaak   +2 more
core   +1 more source