Results 61 to 70 of about 45,432 (269)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu   +7 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

open access: yesAdvanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang   +13 more
wiley   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao   +10 more
wiley   +1 more source

Text in modeling the language consciousness of foreign students

open access: yesАктуальні проблеми української лінгвістики: теорія і практика, 2020
DOI: https://doi.org/10.17721/APULTP.2020.41.177-193 The article considers the text as the main tool in the process of learning the Ukrainian language for foreign students. The text helps not only in learning the foreign language, but also in learning
Olga Zlotnyk-Shagina
doaj  

Designing and Piloting a Tool for the Measurement of the Use of Pronunciation Learning Strategies [PDF]

open access: yes, 2010
What appears to be indispensable to drive the field forward and ensure that research findings will be comparable across studies and provide a sound basis for feasible pedagogic proposals is to draw up a classification of PLS and design on that basis a ...
A. Cohen   +26 more
core   +1 more source

Photocatalytic Asymmetric C‐C Coupling for CO2 Reduction on Cu‐Zn Bimetallic Catalysts with Dipole‐Limiting Effects

open access: yesAdvanced Science, EarlyView.
Asymmetric Cu–Zn dual sites on EDTA‐grafted Ti‐MOF amplify the dipole‐limiting domain field (DLDF), facilitating C–C coupling. This strategy yields an exceptional C2H4 production rate of 308.72 µmol g−1 h−1 with 98.4% electron selectivity in photocatalytic CO2 reduction, highlighting the potential of asymmetric site engineering and local field ...
Peidong Ma   +8 more
wiley   +1 more source

Efficient coding in dolphin surface behavioral patterns [PDF]

open access: yes, 2009
We show that the law of brevity, i.e. the tendency of words to shorten as their frequency increases, is also found in dolphin surface behavioral patterns. As far as we know, this is the first evidence of the law in another species, suggesting that coding
Ferrer Cancho, Ramon, Lusseau, David
core   +2 more sources

Consumer Preferences for Craft Beer: The Interplay of Localness and Advertising Language

open access: yesAgribusiness, EarlyView.
ABSTRACT This study explores the influence of the language of the label, origin of production, and origin of brewing ingredients on Croatian consumers' preferences and willingness to pay for organic craft beer. Employing an online survey and a choice experiment among 223 Croatian alcohol consumers, we find that while there's a willingness to pay a ...
Marija Cerjak   +2 more
wiley   +1 more source

Semiotic resources of gustatory modality in healthy beverage advertising (based on English)

open access: yesАктуальні проблеми української лінгвістики: теорія і практика
This article analyzes semiotic resources used to describe gustatory qualities of juice, sparkling water, functional beverages, tea, coffee, and plant-based milk on the websites of 25 beverage manufacturers.
Andrii Rybalchenko
doaj   +1 more source

Wang Li (1900-1986) [PDF]

open access: yes, 2010
Wang Li (Wang Liaoyi) was one of the three most prominent linguists in China in the 20th century.
LaPolla, Randy J.
core  

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