Results 211 to 220 of about 18,483,123 (229)
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Kinetic suppression of translational errors by (p)ppGpp
Molecular and General Genetics MGG, 1982The effect of (p)ppGpp on the accuracy of translation was studied in vitro using a poly(U)-programmed poly(Phe)-synthesizing system operating at incorporation rates and missense error frequencies close to the values obtained in vivo. Simulation of a relaxed phenotype in vitro was accomplished by limitation of the cognate aminoacyl-tRNA synthetase ...
E. Gerhart +3 more
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(p)ppGpp: the magic governor of bacterial growth economy
Current Genetics, 2019A fundamental question in microbiology is how bacterial cells manage to coordinate gene expression with cell growth during adapting to various environmental conditions. Although the cellular responses to changing environments have been extensively studied using transcriptomic and proteomic approaches, it remains poorly understood regarding the ...
Manlu Zhu, Yige Pan, Xiongfeng Dai
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Mutations that overcome plasmid-mediated relaxation affect (p)ppGpp
Molecular and General Genetics MGG, 1980A recombinant plasmid, pMY3, was constructed in this laboratory to express the amber suppressor allele, Su+7, of the tRNATrp gene from E. coli (Yarus, 1979a). This plasmid also relaxes control of the synthesis of all stable RNA species in its host cell after amino acid deprivation.
L, Breeden, M, Yarus
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The FEBS Journal
The roles of (p)ppGpp in regulating cytosolic proteins are well established; however, their effects on membrane remodeling remain elusive. The translocation of signal recognition particle (SRP)‐dependent proteins can be modulated through (p)ppGpp binding
Sunyong Han +3 more
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The roles of (p)ppGpp in regulating cytosolic proteins are well established; however, their effects on membrane remodeling remain elusive. The translocation of signal recognition particle (SRP)‐dependent proteins can be modulated through (p)ppGpp binding
Sunyong Han +3 more
semanticscholar +1 more source
Selective Fluorescent Chemosensor for the Bacterial Alarmone (p)ppGpp
Journal of the American Chemical Society, 2008We have developed the first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p)ppGpp from among other nucleotides in water. PyDPA was used for the real-time detection of in vitro ppGpp synthesis by bacterial ribosomal complexes.
Rhee, Hyun-Woo +7 more
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Control of bacterial transcription, translation and replication by (p)ppGpp
Current Opinion in Microbiology, 2008The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response to nutritional stress. In Escherichia coli, the enzymes RelA and SpoT are triggered by different starvation signals to produce (p)ppGpp. In many Gram-positive bacteria this is carried out by RelA and two small homologs. (p)ppGpp, along with the transcription factor
Anjana, Srivatsan, Jue D, Wang
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Dependence of RelA-Mediated (p)ppGpp Formation on tRNA Identity
Biochemistry, 2011The bacterial stringent response is a cellular response to amino acid limitations and is characterized by the accumulation of the alarmone polyphosphate guanosine ((p)ppGpp). A key molecular event leading to (p)ppGpp synthesis is the binding of a deacylated tRNA to the vacant A-Site of a ribosome.
Roshani, Payoe, Richard P, Fahlman
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Silence the alarm: (p)ppGpp reduces the expression of key innate immune system regulatory genes 3177
Journal of ImmunologyThe GTP-derived alarmones, guanosine tetra- and pentaphosphate (collectively referred to as (p)ppGpp) are well-established mediators of the nutrient starvation response in many pathogenic bacterial genera.
Ryan P Kilduff +2 more
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A Chemo‐Enzymatic Approach for the Synthesis of C7‐Substituted (p)ppGpp Derivatives†
Chinese journal of chemistryMore modifiable sites on the nucleoside motif may need to be explored for developing novel (p)ppGpp molecular tools. Herein, we report for the first time that the C7‐substituted deazapurine nucleoside triphosphates bearing small modifications as ...
Bianbian Huo +7 more
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New horizons for (p)ppGpp in bacterial and plant physiology
Trends in Microbiology, 2006A hyperphosphorylated guanosine nucleotide, (p)ppGpp, was initially identified as the effector molecule responsible for the stringent response in Escherichia coli. However, a rapidly growing number of reports proves that (p)ppGpp-mediated regulation is conserved in many bacteria and even in plants.
Kristien, Braeken +4 more
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