Results 121 to 130 of about 163,164 (293)

An interactive method of inducing operator descriptions

, 2002
Specifying operator descriptions for planning domain models, especially using standard pre- and post condition symbolism, is a slow and painstaking process.
Richardson, N.E., McCluskey, T.L., Simpson, R.M.   +2 more
core  

Maximal ideals in the algebra of operators on certain Banach spaces. [PDF]

, 2002
For a Banach space $\mathfrak{X}$, let $\mathcal{B}(\mathfrak{X})$ denote the Banach algebra of all continuous linear operators on $\mathfrak{X}$. First, we study the lattice of closed ideals in $\mathcal{B}(\mathfrak{J}_p)$, where $1 < p < \infty$ and $\
Laustsen, Niels Jakob, Laustsen, Niels J.   +1 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

On the modified beta approximating operators of first kind

Journal of Numerical Analysis and Approximation Theory, 2004
We define a general linear operator from which we obtain as special case the modified beta first kind operator\[(B_{p,q}f)(x)={B(p,q)}\int_0^1 t^{p-1}(1-t)^{q-1}f\left({B(p,q)}{B(p+a,q)}t^a x\right){\rm d}t.\]We consider here only the cases \(a=1\) and \
Vasile Miheşan
doaj   +2 more sources

Infinitely Many Solutions for a Steklov Problem Involving the p(x)-Laplacian Operator

پژوهش‌های ریاضی, 2018
By using variational methods and critical point theory for smooth functionals defined on a reflexive Banach space, we establish the existence of infinitely many weak solutions for a Steklov problem involving the p(x)-Laplacian depending on two parameters.
Armin Hadjian
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Optimal domains and integral representations of convolution operators in L-P(G)

, 2004
Given 1 ≤ p < ∞, a compact abelian group G and a function g ∈ L1 (G), we identify the maximal (i.e. optimal) domain of the convolution operator Cg (p) : f ↦ f * g (as an operator from Lp(G) to itself).
Ricker, Werner J., Okada, Susumu, Ricker, W.J   +2 more
core   +1 more source